Ali M, Clos J
Biol Neonate. 1986;49(3):158-67. doi: 10.1159/000242526.
The effect of congenital thyroid deficiency upon the postnatal development of the rat kidney has been studied by measuring the nucleic acid, protein and lipid contents, and the area and thickness of the different regions in the organ, i.e. cortex, outer and inner medulla. Thyroid deficiency, induced by daily propylthiouracil treatment, strongly affects the development of the renal cortex. The medulla, and still more its inner part which develops early and partly before the onset of thyroid function, is relatively preserved. These effects are completely corrected by daily thyroxine therapy, excluding a possible toxic effect of the antithyroid drug. Moreover, they are partly reversible after cessation of propylthiouracil treatment.
通过测量核酸、蛋白质和脂质含量以及器官不同区域（即皮质、外髓质和内髓质）的面积和厚度，研究了先天性甲状腺功能减退对大鼠肾脏出生后发育的影响。通过每日给予丙硫氧嘧啶诱导甲状腺功能减退，会强烈影响肾皮质的发育。髓质，尤其是其早期发育且部分在甲状腺功能开始之前发育的内部，相对得以保留。每日给予甲状腺素治疗可完全纠正这些影响，排除了抗甲状腺药物可能的毒性作用。此外，在停止丙硫氧嘧啶治疗后，这些影响部分是可逆的。
