Ruel J, Coulombe P, Dussault J H
Am J Physiol. 1982 Jun;242(6):E378-83. doi: 10.1152/ajpendo.1982.242.6.E378.
We studied the effects of thyroid hormones and malnutrition on protein, DNA, and phospholipid content of the developing rat lung during the first month of life. Neonatal hypothyroidism significantly decreases the lung phospholipid content by 30-45% between 5 and 30 days of age whether the results are expressed per milligram DNA or per gram tissue. Administration of thyroxine for 3 days to hypothyroid rats increases significantly (20%) their total phospholipid content, mainly through its preferential effect on phosphatidylcholine (50% increase). Adult animal response to thyroid hormones is markedly different from that observed in young rats for most parameters examined. In malnourished rats, lung tissue phospholipids are decreased per cell but not per unit cell mass after 11 days of age. These results show that hypothyroidism has a specific effect on lung phospholipids during the neonatal period.
我们研究了甲状腺激素和营养不良对出生后第一个月内发育中大鼠肺脏蛋白质、DNA和磷脂含量的影响。无论结果以每毫克DNA还是每克组织表示，新生期甲状腺功能减退都会在5至30日龄期间使肺脏磷脂含量显著降低30%-45%。给甲状腺功能减退的大鼠连续3天注射甲状腺素，可使其总磷脂含量显著增加（20%），主要是通过其对磷脂酰胆碱的优先作用（增加50%）。对于大多数检测参数，成年动物对甲状腺激素的反应与幼鼠明显不同。在营养不良的大鼠中，11日龄后肺组织磷脂含量按细胞计算减少，但按单位细胞质量计算未减少。这些结果表明，甲状腺功能减退在新生儿期对肺脏磷脂有特定影响。
