Pattengale P K, Frith C H
Crit Rev Toxicol. 1986;16(3):185-212. doi: 10.3109/10408448609037464.
The present review focuses on the mouse as an experimental immunopathologic model for non-Hodgkins' lymphomas and related leukemias. Immunomorphologic evidence will be presented which demonstrates that B and T cell subtypes of mouse lymphoid cell neoplasms resemble and are analogous to B and T cell subtypes of human lymphoid cell neoplasms. The many experimental advantages of the mouse system will be stressed with a particular emphasis on the concept that this newly defined immunomorphologic approach should be effectively combined with biologic, molecular, and cytogenetic parameters.
本综述聚焦于小鼠作为非霍奇金淋巴瘤及相关白血病的实验性免疫病理模型。将展示免疫形态学证据，其表明小鼠淋巴样细胞瘤的B细胞和T细胞亚型与人类淋巴样细胞瘤的B细胞和T细胞亚型相似且具有可比性。将着重强调小鼠系统的诸多实验优势，尤其强调这一最新定义的免疫形态学方法应与生物学、分子和细胞遗传学参数有效结合的概念。
