Pattengale P K, Stewart T A, Leder A, Sinn E, Muller W, Tepler I, Schmidt E, Leder P
Department of Pathology, Childrens Hospital, Los Angeles, CA 90027.
Am J Pathol. 1989 Jul;135(1):39-61.
This present review focuses on spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes. The historical development of transgenic mice as in vivo disease models is briefly traced, followed by a brief description of the actual technology in such systems. Additional emphasis is placed on the concept of targeting activated cellular oncogenes to specific tissues in transgenic mice. Cumulative experience with activated (Vmyc, ras, and neu (erb-B2] oncogenes in transgenic mice is considered in detail, with particular attention paid to the observed pathology, as well as to the kinetics of disease occurrence. It is concluded that transgenic mice offer the interested investigator(s) an excellent prospective, in vivo model of oncogenesis.
本综述聚焦于携带并表达活化细胞癌基因的转基因小鼠中发生的自发性肿瘤。简要追溯了转基因小鼠作为体内疾病模型的历史发展，随后简要描述了此类系统中的实际技术。还特别强调了将活化细胞癌基因靶向转基因小鼠特定组织的概念。详细讨论了转基因小鼠中活化（Vmyc、ras和neu（erb-B2））癌基因的累积经验，尤其关注观察到的病理学以及疾病发生的动力学。得出的结论是，转基因小鼠为感兴趣的研究者提供了一个出色的肿瘤发生体内前瞻性模型。
