Hornbeak Dana M, Tamhankar Madhura A, Eckstein Lauren A
Department of Ophthalmology, Scheie Eye Institute , Philadelphia, Pennsylvania , USA and.
Orbit. 2014 Feb;33(1):72-4. doi: 10.3109/01676830.2013.851252. Epub 2013 Nov 8.
Thyroid eye disease (TED) is an autoimmune inflammatory disorder that affects the extraocular soft tissues and causes eyelid retraction, proptosis and restrictive extraocular myopathy. Compressive optic neuropathy from extraocular muscle enlargement occurs in less than 5% of patients, in the majority of whom it develops within 18 months of the diagnosis of hyperthyroidism. Vision loss from compressive optic neuropathy in patients with thyroid eye disease is usually bilateral and insidious in onset and progression and is associated with diplopia and elevated intraocular pressure. To our knowledge, there have been no reported cases of acute vision loss to the level of no light perception secondary to thyroid orbitopathy. The authors report a 66-year-old Caucasian male with history of long-standing thyroid eye disease and massive proptosis who progressed from mild compressive symptoms to no light perception within days, despite being clinically stable for over 10 years.
甲状腺眼病（TED）是一种自身免疫性炎症性疾病，会影响眼外软组织，并导致眼睑退缩、眼球突出和限制性眼外肌病。眼外肌肿大引起的压迫性视神经病变在不到5%的患者中出现，其中大多数在甲状腺功能亢进症诊断后的18个月内发生。甲状腺眼病患者因压迫性视神经病变导致的视力丧失通常是双侧的，起病和进展隐匿，并与复视和眼压升高有关。据我们所知，尚无因甲状腺眼眶病继发急性视力丧失至无光感水平的病例报道。作者报告了一名66岁的白种男性，有长期甲状腺眼病和严重眼球突出病史，尽管临床稳定超过10年，但在数天内从轻度压迫症状发展至无光感。
