Ting D S J, Perez-Lopez M, Chew N J, Clarke L, Dickinson A J, Neoh C
Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
Eye (Lond). 2015 Sep;29(9):1162-6. doi: 10.1038/eye.2015.95. Epub 2015 Jun 5.
To review the histopathological diagnoses, visual outcome, and complication rate of orbital biopsy in a UK tertiary referral centre.
This was a retrospective, clinical-pathological, interventional, consecutive case series. All orbital biopsies performed between July 2004 and June 2014 in Newcastle Eye Centre (Newcastle upon Tyne, UK) were included in this study. All relevant data collected from the local electronic database and medical records were analysed.
A total of 166 orbital biopsies were identified during the study period: 86 patients (53.1%) were female and the mean age was 53.7 ± 19.7 years. Of all the cases, orbital biopsies were performed unilaterally in 158 (97.5%) patients and bilaterally in 4 (2.5%) patients. The mean follow-up period was 2.2 ± 2.3 years. The two most common histopathological diagnoses were non-specific inflammatory disease (62, 38.3%) and lymphoproliferative disease (40, 24.7%). None of the patients experienced ≥ 2-Snellen line visual loss. There were 7 (4.2%) postoperative complications noted: 1 (0.6%) orbital haemorrhage with no loss of vision, 4 (2.4%) diplopia, 1 (0.6%) short-term symblepharon, and 1 (0.6%) conjunctival granuloma. Postoperative diplopia was associated with lateral orbitotomy (P = 0.044) and excisional biopsy (P = 0.015).
Orbital biopsy serves as a safe diagnostic tool in managing orbital diseases. Patient should be made aware of the risk of postoperative diplopia. Our data provides useful guidance to clinicians when counselling patients for orbital biopsy.
回顾英国一家三级转诊中心眼眶活检的组织病理学诊断、视力预后及并发症发生率。
这是一项回顾性、临床病理、干预性、连续病例系列研究。纳入2004年7月至2014年6月在英国泰恩河畔纽卡斯尔市纽卡斯尔眼科中心进行的所有眼眶活检病例。分析从当地电子数据库和病历中收集的所有相关数据。
研究期间共确定166例眼眶活检病例：86例（53.1%）为女性，平均年龄为53.7±19.7岁。所有病例中，158例（97.5%）患者为单侧眼眶活检，4例（2.5%）患者为双侧眼眶活检。平均随访期为2.2±2.3年。两种最常见的组织病理学诊断是非特异性炎症性疾病（62例，38.3%）和淋巴增殖性疾病（40例，24.7%）。没有患者视力下降≥2行Snellen视力表视力。记录到7例（4.2%）术后并发症：1例（0.6%）眼眶出血但未导致视力丧失，4例（2.4%）复视，1例（0.6%）短期睑球粘连，1例（0.6%）结膜肉芽肿。术后复视与外侧眶切开术（P = 0.044）和切除活检（P = 0.015）相关。
眼眶活检是管理眼眶疾病的一种安全诊断工具。应让患者了解术后复视的风险。我们的数据为临床医生在为患者进行眼眶活检咨询时提供了有用的指导。
