Department of Psychology and MRC and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge 23EB, UK.
Cell Rep. 2013 Nov 14;5(3):759-68. doi: 10.1016/j.celrep.2013.09.027. Epub 2013 Oct 24.
Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an "as-needed" basis for pattern separation.
成功的记忆不仅包括随着时间的推移记住信息，还包括保持记忆的鲜明性和减少混淆。为了使相似输入模式的表示彼此之间更加不同，已经提出了一种计算过程，称为“模式分离”。在这项工作中，我们开发了一组行为条件，使我们能够在记忆的不同阶段操纵模式分离的负载。因此，我们提供了实验证据，表明脑源性神经营养因子（BDNF）依赖性的模式分离过程发生在记忆处理的编码/存储/巩固阶段，而不是检索阶段。我们还发现，海马齿状回中 BDNF 的自发增加与暴露于地标有关，地标划定了相似但不相似的空间位置，这表明 BDNF 是根据模式分离的“需要”表达的。
