Clelland C D, Choi M, Romberg C, Clemenson G D, Fragniere A, Tyers P, Jessberger S, Saksida L M, Barker R A, Gage F H, Bussey T J
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Science. 2009 Jul 10;325(5937):210-3. doi: 10.1126/science.1173215.
The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.
哺乳动物海马体的齿状回（DG）被认为介导模式分离——记忆信息的独特且正交表征的形成——并且在整个生命过程中都经历神经发生。神经发生如何促进海马体功能在很大程度上尚不清楚。我们使用成年小鼠，其中海马体神经发生被消融，通过两种行为试验发现了空间辨别方面的特定损伤：（i）空间导航放射状臂迷宫任务，以及（ii）小鼠触摸屏上的空间但不可导航任务。当刺激呈现时空间分离很小时，神经发生被消融的小鼠会受损，但当刺激在空间上分离更宽时则不会。因此，新生神经元对于成年小鼠DG中的正常模式分离功能可能是必需的。
