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[聚焦超声治疗:神经外科的现状与潜在应用]

[Focused ultrasound therapy: current status and potential applications in neurosurgery].

作者信息

Dervishi E, Aubry J-F, Delattre J-Y, Boch A-L

机构信息

Équipe de neuro-oncologie expérimentale, Inserm, UMRS 975, CNRS 7225, institut du cerveau et de la moelle épinière, groupe hospitalier La Pitié Salpêtrière-Charles-Foix, Assistance publique-Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75651 Paris, France.

出版信息

Neurochirurgie. 2013 Dec;59(6):201-9. doi: 10.1016/j.neuchi.2013.06.005. Epub 2013 Nov 5.

Abstract

High Intensity Focused Ultrasound (HIFU) therapy is an innovative approach for tissue ablation, based on high intensity focused ultrasound beams. At the focus, HIFU induces a temperature elevation and the tissue can be thermally destroyed. In fact, this approach has been tested in a number of clinical studies for the treatment of several tumors, primarily the prostate, uterine, breast, bone, liver, kidney and pancreas. For transcranial brain therapy, the skull bone is a major limitation, however, new adaptive techniques of phase correction for focusing ultrasound through the skull have recently been implemented by research systems, paving the way for HIFU therapy to become an interesting alternative to brain surgery and radiotherapy.

摘要

高强度聚焦超声(HIFU)疗法是一种基于高强度聚焦超声束的组织消融创新方法。在焦点处,HIFU会引起温度升高,从而使组织被热破坏。事实上,这种方法已在多项临床研究中用于治疗多种肿瘤,主要是前列腺、子宫、乳腺、骨、肝、肾和胰腺肿瘤。然而,对于经颅脑部治疗,颅骨是一个主要限制因素。不过,研究系统最近已采用新的自适应相位校正技术来聚焦穿过颅骨的超声,为HIFU疗法成为脑外科手术和放射治疗的一种有吸引力的替代方案铺平了道路。

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