Division of Psychology, Birmingham City University, United Kingdom.
Res Dev Disabil. 2013 Dec;34(12):4310-8. doi: 10.1016/j.ridd.2013.09.004. Epub 2013 Oct 25.
This study aimed to highlight the occurrence of autism spectrum disorders (ASDs) in children with septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH). A cross-sectional study was designed, including 28 children with SOD and 14 children with ONH. Clinician diagnosis of ASD was reported in 14 children. The Social Communication Questionnaire (SCQ) reported that 23 children met the cut-off point for ASD, and 9 children met the cut-off point for autism. Greater levels of intellectual disability and visual loss were reported in children with ASD in comparison to those without ASD, but, of the two, intellectual disability was a better predictor for ASD. The SCQ lost its sensitivity and specificity in children who had greater visual loss which highlights a requirement for a measure that is sensitive to visual loss. It is also recommended that children with SOD/ONH would benefit from routine screening for ASDs.
本研究旨在强调在患有颅咽管发育不良（SOD）和视神经发育不良（ONH）的儿童中自闭症谱系障碍（ASD）的发生情况。设计了一项横断面研究，包括 28 名 SOD 患儿和 14 名 ONH 患儿。报告了 14 名儿童的 ASD 临床医生诊断。社交沟通问卷（SCQ）报告说，23 名儿童达到了 ASD 的截止点，9 名儿童达到了自闭症的截止点。与无 ASD 的儿童相比，患有 ASD 的儿童智力残疾和视力丧失程度更高，但在这两者中，智力残疾是 ASD 的更好预测指标。对于视力丧失程度更大的儿童，SCQ 失去了敏感性和特异性，这突出了需要一种对视力丧失敏感的测量方法。还建议对患有 SOD/ONH 的儿童进行 ASD 常规筛查。
