下肢皮肤鳞状细胞癌：鳞状细胞癌的一个独特亚型。
Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas.
机构信息
Department of Dermatology, Yale University, New Haven, Connecticut.
Department of Dermatology, Yale University, New Haven, Connecticut; Department of Pathology, Yale University, New Haven, Connecticut.
出版信息
J Am Acad Dermatol. 2014 Jan;70(1):70-4. doi: 10.1016/j.jaad.2013.09.026. Epub 2013 Nov 5.
BACKGROUND
Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE).
OBJECTIVE
We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs.
METHODS
We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded.
RESULTS
Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients.
LIMITATIONS
The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population.
CONCLUSIONS
LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.
背景
一些患者下肢（LE）会出现数量不成比例的皮肤鳞状细胞癌（SCC）。
目的
我们旨在描述多发性 LE SCC 患者的临床特征、治疗和结局。
方法
我们在 4.5 年的研究期间确定了 22 名患有 4 个或更多活检诊断为 LE SCC 的患者。记录了每个 LE SCC 的位置、大小、治疗和临床结局。
结果
在所研究的 22 名患者中，有 18 名女性。我们的患者共发生了 360 个 SCC，其中 260 个（72.2%）位于 LE。这些患者 SCC 的发生率比同一患者基底细胞癌的发生率高近 7 倍。
局限性
患者数量较少，限制了对一般人群中 LE SCC 患病率的明确结论。
结论
LE SCC 是皮肤 SCC 的一个独特亚群，可能具有独特的临床特征和生物学行为，需要进一步研究。
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