Sydney School of Public Health, University of Sydney, Sydney, Australia.
Sydney School of Public Health, University of Sydney, Sydney, Australia.
J Am Acad Dermatol. 2014 Mar;70(3):456-64. doi: 10.1016/j.jaad.2013.11.009. Epub 2013 Dec 25.
Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) have poorer outcomes if treated when large.
We sought to estimate the growth rate of BCCs and SCCs and examine the relationship of personal, pathway, and cancer factors with cancer size (diameter).
We surveyed patients, pathology, and treatment for invasive BCCs and SCCs in 1 Australian region in 2000 through 2001.
BCC size increased with increasing time since first noticed. Relative to mean size at 0 to 2 months, the mean size ratio was 1.10 at 2 to 8 months and increased steadily to 1.81 at 5 to 10 years (P < .001). Few BCCs were untreated beyond 10 years. There was no consistent evidence that SCC size increased with increasing time. Larger BCCs were independently associated with older age, male sex, no skin checks by a physician, aggressive tumor type, ulceration and lesion-associated scar tissue, and larger SCCs with male sex, skin checks by a physician every 1 to 3 months, and location on limbs.
Patient recall of dates and lack of thickness for SCCs are limitations.
Earlier diagnosis of BCCs, perhaps through skin checks by a physician, may reduce their size and improve outcome. SCC size did not evidently increase with time.
如果基底细胞癌（BCC）和鳞状细胞癌（SCC）在较大时进行治疗，其预后较差。
我们旨在评估 BCC 和 SCC 的生长速度，并探讨个人、治疗途径和癌症相关因素与癌症大小（直径）的关系。
我们调查了 2000 年至 2001 年期间澳大利亚某一地区侵袭性 BCC 和 SCC 患者的个人信息、病理和治疗情况。
BCC 大小随首次发现后的时间推移而增加。与 0 至 2 个月时的平均大小相比，2 至 8 个月时的平均大小比为 1.10，且稳定增加至 5 至 10 年时的 1.81（P<0.001）。10 年以上未经治疗的 BCC 很少见。没有证据表明 SCC 大小随时间推移而增加。更大的 BCC 与年龄较大、男性、无医生皮肤检查、侵袭性肿瘤类型、溃疡和病变相关的疤痕组织以及更大的 SCC 与男性、每 1-3 个月由医生进行皮肤检查、位于四肢有关。
患者对日期的回忆和 SCC 厚度的缺乏是局限性。
通过医生进行皮肤检查，可能更早地诊断 BCC，从而缩小其大小并改善预后。SCC 大小并未随时间明显增加。
