Department of Dermatology, University of Tübingen, Germany.
Int J Oral Maxillofac Surg. 2011 Sep;40(9):943-8. doi: 10.1016/j.ijom.2011.02.036. Epub 2011 May 19.
In a prospective study, a large number of patients with basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) underwent surgery using three dimensional (3D) histology and were evaluated with respect to local recurrence. The excised tumours were treated using 3D-histology with a routine paraffin procedure until the surgical margins were clear of tumour. Prospective evaluation of recurrence-free survival and overall survival of 5227 primary BCCs in 3320 patients and 615 invasive primary SCCs in 600 patients was conducted in the form of a letter-based follow-up with feedback from the patients and the referring physicians. The mean follow-up period was 5 years. In the BCC collective, 36 out of 3320 patients developed local recurrence (1%, calculated as a percentage of treated BCCs: 0.7%). In the SCC collective, 20 local recurrences appeared (3%). The recurrence rate for SCCs with desmoplasia was 24%, whilst the recurrence rate for common types of SCC without desmoplasia was 1%. Surgery followed by 3D histology results in very low recurrence rates for BCC and SCC with no additional effort compared with the normal histopathological procedure.
在一项前瞻性研究中，大量基底细胞癌（BCC）和鳞状细胞癌（SCC）患者接受了三维（3D）组织学手术，并就局部复发情况进行了评估。切除的肿瘤采用 3D 组织学和常规石蜡程序进行处理，直到手术边缘无肿瘤为止。对 3320 例患者的 5227 例原发性 BCC 和 600 例侵袭性原发性 SCC 进行了基于信件的无复发生存和总体生存的前瞻性评估，并从患者和转诊医生那里获得了反馈。平均随访时间为 5 年。在 BCC 组中，3320 例患者中有 36 例出现局部复发（1%，按治疗 BCC 的百分比计算：0.7%）。在 SCC 组中，出现了 20 例局部复发（3%）。有纤维母细胞增生的 SCC 的复发率为 24%，而无纤维母细胞增生的常见类型 SCC 的复发率为 1%。与常规组织病理学程序相比，3D 组织学后手术可使 BCC 和 SCC 的复发率非常低，且无需额外努力。
