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情绪应激对E1小鼠惊厥的影响及其生化背景。

Effects of emotional stress on E1-mouse convulsions, and their biochemical background.

作者信息

Mori A, Hiramatsu M, Kabuto H, Marescau B

出版信息

Neurochem Res. 1986 Jan;11(1):37-45. doi: 10.1007/BF00965163.

DOI:10.1007/BF00965163
PMID:2421176
Abstract

Emotional stress markedly inhibited E1 mouse convulsions. Norepinephrine and dopamine levels in E1 mouse brain were hardly affected by stress, though a marked decrease in norepinephrine and dopamine levels was observed in the ddY mouse brain. The serotonin levels decreased in the E1 mouse brain in the same degree as in the ddY mouse brain. These findings suggest that the serotonergic system is involved in the inhibition of E1 mouse convulsions, through an enhanced serotonin release in the brain brought on by the emotional stress. Noradrenergic and dopaminergic systems may also be involved.

摘要

情绪应激显著抑制E1小鼠惊厥。E1小鼠脑中去甲肾上腺素和多巴胺水平几乎不受应激影响,不过在ddY小鼠脑中观察到去甲肾上腺素和多巴胺水平显著降低。E1小鼠脑中血清素水平下降程度与ddY小鼠脑相同。这些发现表明,血清素能系统通过情绪应激引起的脑中血清素释放增加参与抑制E1小鼠惊厥。去甲肾上腺素能和多巴胺能系统可能也参与其中。

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本文引用的文献

1
Time-related differences in noradrenaline turnover in rat brain regions by stress.
Pharmacol Biochem Behav. 1982 Feb;16(2):315-9. doi: 10.1016/0091-3057(82)90166-6.
2
Brain monoamine levels and E1 mouse convulsions.脑单胺水平与E1小鼠惊厥
Folia Psychiatr Neurol Jpn. 1981;35(3):261-6. doi: 10.1111/j.1440-1819.1981.tb00224.x.
3
Determination of picomole amounts of dopamine, noradrenaline, 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindolacetic acid in nervous tissue after one-step purification on Sephadex G-10, using high-performance liquid chromatography with a novel type of electrochemical detection.采用新型电化学检测的高效液相色谱法,在Sephadex G - 10上一步纯化后,测定神经组织中皮摩尔量的多巴胺、去甲肾上腺素、3,4 - 二羟基苯丙氨酸、3,4 - 二羟基苯乙酸、高香草酸和5 - 羟基吲哚乙酸。
J Neurochem. 1981 Apr;36(4):1449-62. doi: 10.1111/j.1471-4159.1981.tb00586.x.
4
Metabolic studies on ep mouse, a special strain with convulsive predisposition.对ep小鼠(一种具有惊厥易感性的特殊品系)的代谢研究。
Prog Brain Res. 1966;21:112-29. doi: 10.1016/s0079-6123(08)62974-x.
5
Paroxysmal discharges in the electroencephalogram of the E1 mouse.E1小鼠脑电图中的阵发性放电。
Experientia. 1976 Mar 15;32(3):336-8. doi: 10.1007/BF01940824.
6
Behavioral despair in mice: a primary screening test for antidepressants.小鼠行为绝望:一种抗抑郁药的初步筛选试验。
Arch Int Pharmacodyn Ther. 1977 Oct;229(2):327-36.
7
Brain catecholamine concentrations and convulsions in E1 mice.E1小鼠的脑儿茶酚胺浓度与惊厥
Folia Psychiatr Neurol Jpn. 1977;31(3):491-5. doi: 10.1111/j.1440-1819.1977.tb02638.x.