表皮生长因子受体（EGFR）在肝癌中的相互作用。
Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer.
机构信息
Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Pamplona 31008, Spain.
出版信息
Cancers (Basel). 2011 May 18;3(2):2444-61. doi: 10.3390/cancers3022444.
Hepatocarcinogenesis is a complex multistep process in which many different molecular pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to conventional chemotherapeutic agents, and the new targeted therapies are meeting with limited success. Interreceptor crosstalk and the positive feedback between different signaling systems are emerging as mechanisms of targeted therapy resistance. The identification of such interactions is therefore of particular relevance to improve therapeutic efficacy. Among the different signaling pathways activated in hepatocarcinogenesis the epidermal growth factor receptor (EGFR) system plays a prominent role, being recognized as a "signaling hub" where different extracellular growth and survival signals converge. EGFR can be transactivated in response to multiple heterologous ligands through the physical interaction with multiple receptors, the activity of intracellular kinases or the shedding of EGFR-ligands. In this article we review the crosstalk between the EGFR and other signaling pathways that could be relevant to liver cancer development and treatment.
肝癌发生是一个复杂的多步骤过程，其中涉及许多不同的分子途径。肝细胞癌（HCC）对传统化疗药物有抗药性，新的靶向治疗方法收效甚微。受体间的串扰和不同信号系统之间的正反馈正成为靶向治疗耐药的机制。因此，确定这些相互作用对于提高治疗效果尤为重要。在肝癌发生过程中激活的不同信号通路中，表皮生长因子受体（EGFR）系统起着突出的作用，被认为是不同的细胞外生长和存活信号汇聚的“信号枢纽”。EGFR 可以通过与多种受体的物理相互作用、细胞内激酶的活性或 EGFR 配体的脱落，对多种异源配体做出反应而被转激活。本文综述了 EGFR 与其他信号通路之间的串扰，这些串扰可能与肝癌的发生和治疗有关。
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