Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, U964 INSERM, Université de Strasbourg, BP 10142, 67404 Illkirch, C.U. de Strasbourg, France.
Cancers (Basel). 2011 Jun 21;3(2):2734-49. doi: 10.3390/cancers3022734.
Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.
肿瘤坏死因子受体相关因子 4（TRAF4）是一种在癌症中表达改变的基因。它在多种不同来源的癌中过表达，通常是由于扩增的结果。TRAF4 编码一种衔接蛋白，属于 TRAF 蛋白家族。虽然大多数 TRAF 蛋白影响免疫和炎症过程，但 TRAF4 主要参与发育和形态发生过程。有趣的是，这种蛋白质已被证明与关键的细胞功能有关，如细胞极性和活性氧物质产生的调节。
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