Shim Ilseob, Seo Gyun-Baek, Oh Eunha, Lee Mimi, Kwon Jung-Taek, Sul Donggeun, Lee Byung-Woo, Yoon Byung-Il, Kim Pilje, Choi Kyunghee, Kim Hyun-Mi
Risk Assessment Division, NIER, Environmental Research Complex, Korea.
J Toxicol Sci. 2013;38(6):937-46. doi: 10.2131/jts.38.937.
Chloramine T has been widely used as a disinfectant in many areas such as kitchens, laboratories and hospitals. It has been also used as a biocide in air fresheners and deodorants which are consumer products; however, little is known about its toxic effects by inhalation route. This study was performed to identify the subacute inhalation toxicity of chloramine T under whole-body inhalation exposure conditions. Male and female groups of rats were exposed to chloramine T at concentrations of 0.2, 0.9 and 4.0 mg/m³ for 6 hr/day, 5 days/week during 4 weeks. After 28-day repeated inhalation of chloramine T, there were dose-dependently significant DNA damage in the rat tissues evaluated and inflammation was histopathologically noted around the terminal airways of the lung in both genders. As a result of the expression of three types of antioxidant enzymes (SOD-2, GPx-1, PRX-1) in rat's lung after exposure, there was no significant change of all antioxidant enzymes in the male and female rats. The results showed that no observed adverse effect level (NOAEL) was 0.2 mg/m³ in male rats and 0.9 mg/m³ in female rats under the present experimental condition.
氯胺T已在许多领域广泛用作消毒剂，如厨房、实验室和医院。它还被用作空气清新剂和除臭剂（这些都是消费品）中的杀生剂；然而，关于其吸入途径的毒性作用知之甚少。本研究旨在确定全身吸入暴露条件下氯胺T的亚急性吸入毒性。将雄性和雌性大鼠组暴露于浓度为0.2、0.9和4.0 mg/m³的氯胺T中，每天暴露6小时，每周暴露5天，持续4周。在对氯胺T进行28天重复吸入后，在所评估的大鼠组织中存在剂量依赖性的显著DNA损伤，并且在两性的肺终末气道周围均观察到组织病理学炎症。暴露后大鼠肺中三种抗氧化酶（SOD-2、GPx-1、PRX-1）的表达结果显示，雄性和雌性大鼠的所有抗氧化酶均无显著变化。结果表明，在本实验条件下，雄性大鼠的未观察到有害作用水平（NOAEL）为0.2 mg/m³，雌性大鼠为0.9 mg/m³。
