乙二醇酸在雄性 Sprague-Dawley 大鼠中的急性和 28 天重复吸入毒性研究。
Acute and 28-Day Repeated Inhalation Toxicity Study of Glycolic Acid in Male Sprague-Dawley Rats.
机构信息
Environmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
出版信息
In Vivo. 2019 Sep-Oct;33(5):1507-1519. doi: 10.21873/invivo.11631.
BACKGROUND/AIM: The use of glycolic acid is present in a variety of consumer products, including medicines, cleaners, cosmetics, and paint strippers. It has recently led to concerns about toxicity from inhalation exposure. Herein, the pulmonary toxicity of glycolic acid was investigated in rats.
MATERIALS AND METHODS
We conducted acute (458 mg/m) and sub-acute (49.5 mg/m) inhalation tests to identify the potential toxicities of glycolic acid.
RESULTS
Inhalation exposure to glycolic acid in the acute and subacute inhalation tests did not cause any specific changes in clinical examinations, including body weight, organ weight, hematology, serum biochemistry, and histopathology. The polymorphonuclear neutrophils (PMNs) and inflammatory cytokines in Bronchoalveolar lavage fluid (BALF) increased in rats exposed to single and repeated inhalations. In the sub-acute test, the changes induced by glycolic acid were minor or returned to normal during the recovery period.
CONCLUSION
The No Observed Adverse Effect Concentration (NOAEC) for the nasal and pulmonary toxicity of glycolic acid was determined to be over 50 mg/m at the end of a 28-day inhalation test in male rats.
背景/目的：乙醇酸在多种消费品中都有应用，包括药品、清洁剂、化妆品和脱漆剂。近期，人们对吸入暴露引起的毒性表示担忧。本文研究了乙醇酸对大鼠肺部的毒性。
材料与方法
我们进行了急性（458mg/m）和亚急性（49.5mg/m）吸入测试，以确定乙醇酸的潜在毒性。
结果
急性和亚急性吸入测试中，乙醇酸吸入暴露并未导致临床检查（包括体重、器官重量、血液学、血清生化学和组织病理学）出现任何特定变化。单次和重复吸入乙醇酸会导致大鼠支气管肺泡灌洗液（BALF）中的多形核粒细胞（PMNs）和炎症细胞因子增加。在亚急性测试中，乙醇酸引起的变化在恢复期较小或恢复正常。
结论
在雄性大鼠 28 天吸入测试结束时，乙醇酸鼻和肺毒性的无观察不良效应浓度（NOAEC）确定为 50mg/m 以上。
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