1Monash University, Clayton Campus, Victoria, Australia.
Neurorehabil Neural Repair. 2014 May;28(4):303-13. doi: 10.1177/1545968313508472. Epub 2013 Nov 8.
Fatigue is a common, persistent complaint following traumatic brain injury (TBI). Effective treatment is not well established.
.The current study aimed to investigate the efficacy of 4 weeks of light therapy for fatigue in patients with TBI.
We undertook a randomized, placebo-controlled study of 4-week, 45 min/morning, home-based treatment with short wavelength (blue) light therapy (λmax = 465 nm, 84.8 µW/cm(2), 39.5 lux, 1.74 × 10(14) photons/cm(2)/s) compared with yellow light therapy (λmax = 574 nm, 18.5 µW/cm(2), 68 lux, 1.21 × 10(12) photons/cm(2)/s) containing less photons in the short wavelength range and a no treatment control group (n = 10 per group) in patients with TBI who self-reported fatigue and/or sleep disturbance. Assessments of fatigue and secondary outcomes (self-reported daytime sleepiness, depression, sleep quality, and sustained attention) were conducted over 10 weeks at baseline (week -2), midway through and at the end of light therapy (weeks 2 and 4), and 4 weeks following cessation of light therapy (week 8).
After controlling age, gender, and baseline depression, treatment with high-intensity blue light therapy resulted in reduced fatigue and daytime sleepiness during the treatment phase, with evidence of a trend toward baseline levels 4 weeks after treatment cessation. These changes were not observed with lower-intensity yellow light therapy or no treatment control conditions. There was also no significant treatment effect observed for self-reported depression or psychomotor vigilance performance.
Blue light therapy appears to be effective in alleviating fatigue and daytime sleepiness following TBI and may offer a noninvasive, safe, and nonpharmacological alternative to current treatments.
疲劳是脑外伤（TBI）后常见的、持续存在的主诉。有效的治疗方法尚未得到很好的建立。
本研究旨在探讨 4 周的强光疗法治疗 TBI 后疲劳的疗效。
我们进行了一项为期 4 周、每天 45 分钟、家庭为基础的研究，比较了短波长（蓝色）光疗法（λmax = 465nm，84.8µW/cm²，39.5lux，1.74×10¹⁴ 光子/cm²/s）与包含较少短波长光子的黄色光疗法（λmax = 574nm，18.5µW/cm²，68lux，1.21×10¹² 光子/cm²/s）以及无治疗对照组（每组 10 例）对 TBI 患者自我报告的疲劳和/或睡眠障碍的治疗效果。在基线（-2 周）、光疗期间中途（2 周和 4 周）和光疗结束后 4 周（8 周），评估疲劳和次要结局（自我报告的白天嗜睡、抑郁、睡眠质量和持续注意力）。
在控制年龄、性别和基线抑郁后，高强度蓝光治疗可减轻治疗期间的疲劳和白天嗜睡，且在治疗结束后 4 周有恢复到基线水平的趋势。这些变化在低强度黄光治疗或无治疗对照组中未观察到。自我报告的抑郁或精神运动警觉性表现也没有观察到显著的治疗效果。
蓝光疗法似乎能有效缓解 TBI 后的疲劳和白天嗜睡，可能为目前的治疗方法提供一种非侵入性、安全、非药物的替代方法。
