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肝切除前后大鼠肝脏在静电场及法拉第笼中的代谢(作者译)

[Metabolism of rat liver in the electrostatic field and in the faraday cage before and after hepatectomy (author's transl)].

作者信息

Klingenberg H G, Möse J R, Fischer G, Porta J, Sadjak A

出版信息

Zentralbl Bakteriol Orig B. 1975 Oct;161(2):137-45.

PMID:242166
Abstract

Investigations were performed with the aim of establishing the influence of various environmental conditions (such as steady field conditions, climatized laboratories, Faraday's cage) on a number of enzymic activities in the rat (including glutamic oxaloacetic tic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, gamma-glutamyl transpeptidase, acid phosphatase), as well as the serum concentrations of triglycerides, the oxygen consumption of hepatic parenchyma cells, and the influence on the incorporation of 3H-thymidine (following partial hepatectomy). In the steady field, the activities of the cytoplasmic enzymes (GOT, GPT, LDH) were higher then under Faraday conditions. The same applies both to the hepatic oxygen consumption and to the neutral fat serum levels. The control values always remained within the range of the results obtained under steady field or Faraday conditions. In the structure-linked enzymes (gamma-glutamyl transpeptidase, acid phosphatase) the results were not uniform. Following partial hepatectomy, and under steady field conditions, the serum triglyceride concentrations showed a less pronounced drop than they did in the controls. Under selected environmental conditions, the results obtained lie within the physiological range. The present findings, therefore, do not permit definite conclusions to be drawn on favourable or unfavourable effects exerted by the different types of electroclimates.

摘要

开展了多项研究,目的是确定各种环境条件(如稳定场条件、气候控制实验室、法拉第笼)对大鼠体内多种酶活性的影响(包括谷草转氨酶、谷丙转氨酶、乳酸脱氢酶、γ-谷氨酰转肽酶、酸性磷酸酶),以及甘油三酯的血清浓度、肝实质细胞的耗氧量,和对(部分肝切除术后)3H-胸腺嘧啶掺入的影响。在稳定场中,细胞质酶(谷草转氨酶、谷丙转氨酶、乳酸脱氢酶)的活性高于在法拉第条件下的活性。这同样适用于肝脏耗氧量和中性脂肪血清水平。对照值始终保持在稳定场或法拉第条件下获得的结果范围内。对于结构相关酶(γ-谷氨酰转肽酶、酸性磷酸酶),结果并不一致。部分肝切除术后,在稳定场条件下,血清甘油三酯浓度的下降幅度比对照组小。在选定的环境条件下,所获得的结果处于生理范围内。因此,目前的研究结果无法就不同类型的电气候所产生的有利或不利影响得出明确结论。

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