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[几种肌肉萎缩中乳酸脱氢酶、谷草转氨酶和谷丙转氨酶的变化。I. 肌腱切断术后的变化]

[Changes in lactate dehydrogenase, glutamate-cxaloacetate transaminase and glutamate-pyruvate transaminase in several muscular atrophies. I. Changes following tenotomy].

作者信息

Gaimandzhiev Kh

出版信息

Eksp Med Morfol. 1973;12(2):66-70.

PMID:4806516
Abstract

The activites of lactic dehydrogenase (LDH), glutamicoxalactic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) are investigated within variable periods following tenotomy of m. gastrocnemius in the rat. A gradual fall of total activities is established, mostly significant for LDH, and least - for GPT. The specific activities undergo similar alterations. Experiments with dialysates show that the changes found are due to a reduced enzyme molecules' synthesis, and not to altered ratios between enzyme activators and inhibitors.

摘要

在大鼠腓肠肌切断术后的不同时间段内,对乳酸脱氢酶(LDH)、谷草转氨酶(GOT)和谷丙转氨酶(GPT)的活性进行了研究。发现总活性逐渐下降,其中LDH下降最为显著,GPT下降最少。比活性也发生了类似的变化。透析液实验表明,所发现的变化是由于酶分子合成减少,而非酶激活剂与抑制剂之间的比例改变所致。

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