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分离的大鼠肝细胞对游离脂肪酸的摄取。

Free fatty-acid uptake by isolated rat hepatocytes.

作者信息

Renaud G, Bouma M E, Foliot A, Infante R

出版信息

Arch Int Physiol Biochim. 1985 Nov;93(4):313-9. doi: 10.3109/13813458509079612.

DOI:10.3109/13813458509079612
PMID:2421669
Abstract

In isolated rat hepatocytes, the rate of palmitic acid binding and uptake is directly related to the concentration of free fatty acid (FFA) in the medium. After their entry into the cell, FFA are immediately incorporated into cellular phospholipids and triglycerides and no accumulation of free fatty acids can be demonstrated inside the cell. The rate of free fatty-acid uptake remains unchanged after incubation in a 2 mM KCN containing medium, indicating that in the range of fatty-acid concentrations used in this study, this phenomenon does not require energy.

摘要

在分离的大鼠肝细胞中,棕榈酸的结合和摄取速率与培养基中游离脂肪酸(FFA)的浓度直接相关。FFA进入细胞后,会立即掺入细胞磷脂和甘油三酯中,且细胞内不会出现游离脂肪酸的积累。在含有2 mM KCN的培养基中孵育后,游离脂肪酸的摄取速率保持不变,这表明在本研究使用的脂肪酸浓度范围内,该现象不需要能量。

相似文献

1
Free fatty-acid uptake by isolated rat hepatocytes.分离的大鼠肝细胞对游离脂肪酸的摄取。
Arch Int Physiol Biochim. 1985 Nov;93(4):313-9. doi: 10.3109/13813458509079612.
2
Essential fatty acid uptake and esterification in primary culture of rat hepatocytes.大鼠肝细胞原代培养中必需脂肪酸的摄取与酯化
Biochim Biophys Acta. 1986 Oct 3;878(3):310-9. doi: 10.1016/0005-2760(86)90238-9.
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Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo.体内组织分离的肝癌7288CTC和7777对血浆脂质的摄取。
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Lipid metabolism of rat liver isolated and perfused in hypoxia.缺氧条件下分离并灌注的大鼠肝脏的脂质代谢
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Effect of increased uptake of plasma fatty acids by the liver on lipid metabolism in the hepatocellular nuclei.肝脏对血浆脂肪酸摄取增加对肝细胞核脂质代谢的影响。
Prostaglandins Leukot Essent Fatty Acids. 1997 Jul;57(1):27-31. doi: 10.1016/s0952-3278(97)90489-0.
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Inhibitory effect of D-galactosamine administration on fatty acid oxidation in rat hepatocytes.给予D-半乳糖胺对大鼠肝细胞脂肪酸氧化的抑制作用。
FEBS Lett. 1982 Aug 23;145(2):267-70. doi: 10.1016/0014-5793(82)80180-4.
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Intestinal metabolism of plasma free fatty acids. Intracellular compartmentation and mechanisms of control.血浆游离脂肪酸的肠道代谢。细胞内区室化及调控机制。
J Clin Invest. 1975 Apr;55(4):803-13. doi: 10.1172/JCI107991.
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Studies on the fate of labelled palmitic acid in rat lung.大鼠肺中标记棕榈酸的代谢研究。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;75(1):179-83. doi: 10.1016/0742-8413(83)90030-0.
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Physical-chemical model for the entry of water-insoluble compounds into cells. Studies of fatty acid uptake by the liver.水不溶性化合物进入细胞的物理化学模型。肝脏对脂肪酸摄取的研究。
Biochemistry. 1986 Apr 22;25(8):2013-21. doi: 10.1021/bi00356a027.
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[Intestinal metabolism of plasma free fatty acids (authors transl)].血浆游离脂肪酸的肠道代谢(作者译)
Wien Klin Wochenschr. 1976 Dec 24;88(24):813-6.

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