Camhi S M, Katzmarzyk P T
Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.
Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Int J Obes (Lond). 2014 Aug;38(8):1142-5. doi: 10.1038/ijo.2013.208. Epub 2013 Nov 12.
Potential differences in body composition between metabolically healthy obese (MHO) and metabolically abnormal obese (OA) adults were explored with 395 obese adults from the Pennington Center Longitudinal Study (18-68 years). Adults were classified as OA (≥2 risk factors: blood pressure ≥130/85 mmHg; triglycerides ≥150 mg dl(-1); high-density lipoprotein cholesterol: men <40, women <50 mg dl(-1); fasting glucose ≥100 mg dl(-1); waist circumference: ≥102 cm men, women ≥88 cm) or MHO (<2 risk factors). Whole-body bone mineral density and content, percent body fat, fat mass, lean mass and trunk adipose tissue mass were measured with dual-energy X-ray absorptiometry. Visceral (VAT), subcutaneous (SAT) and total abdominal adipose tissue (TAT) were measured with computed tomography. Gender-specific general linear regression models were used to determine differences in body composition between MHO and OA controlling for age, race, smoking status and menopause status. In men, MHO had lower fat mass (kg and %), trunk adipose tissue, VAT, SAT, TAT and lean mass compared with OA. MHO women had lower fat mass (kg), lean mass, trunk adipose tissue, VAT and TAT when compared with OA women. In conclusion, OA and MHO cardiometabolic profiles are characterized by differences in body composition consistent between genders.
利用彭宁顿中心纵向研究中的395名肥胖成年人（年龄在18 - 68岁之间），探讨了代谢健康型肥胖（MHO）和代谢异常型肥胖（OA）成年人在身体成分方面的潜在差异。成年人被分为OA（≥2个风险因素：血压≥130/85 mmHg；甘油三酯≥150 mg dl⁻¹；高密度脂蛋白胆固醇：男性<40，女性<50 mg dl⁻¹；空腹血糖≥100 mg dl⁻¹；腰围：男性≥102 cm，女性≥88 cm）或MHO（<2个风险因素）。采用双能X线吸收法测量全身骨矿物质密度和含量、体脂百分比、脂肪量、瘦体重和躯干脂肪组织量。通过计算机断层扫描测量内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和腹部总脂肪组织（TAT）。使用性别特异性的一般线性回归模型来确定在控制年龄、种族、吸烟状况和绝经状态的情况下，MHO和OA在身体成分方面的差异。在男性中，与OA相比，MHO的脂肪量（kg和%）、躯干脂肪组织、VAT、SAT、TAT和瘦体重更低。与OA女性相比，MHO女性的脂肪量（kg）、瘦体重、躯干脂肪组织、VAT和TAT更低。总之，OA和MHO的心脏代谢特征表现为身体成分方面的差异，且在性别之间具有一致性。
