Mathew Raeba, Pefkianaki Maria, Kopsachilis Nickolaos, Brar Manpreet, Richardson Matthew, Sivaprasad Sobha
Laser and Retinal Research Unit, Department of Ophthalmology, King's College Hospital, London, UK.
Ophthalmologica. 2014;231(3):153-9. doi: 10.1159/000355091. Epub 2013 Nov 6.
To assess the sensitivity and specificity of spectral-domain optical coherence tomography (SDOCT) for the determination of choroidal neovascularization (CNV) subtypes in neovascular age-related macular degeneration (AMD) compared to fundus fluorescein angiography (FFA) and also the agreement between the two procedures.
This was a retrospective, observational study.
We evaluated and compared the CNV subtypes on FFA and OCT in 100 eyes initiated on ranibizumab for neovascular AMD.
SDOCT showed high sensitivity (85.7-98.3%) and specificity (84.2-100%) compared to FFA in the diagnosis of the CNV subtype. The area under the receiver-operating characteristic curve ranged from 0.9 to 0.93 (p value <0.0001) for the different CNV subtypes. Weighted kappa statistics showed a near-perfect agreement of 0.85 between the procedures.
SDOCT is a reliable tool for the diagnosis of CNV subtypes in neovascular AMD obviating the need for an invasive procedure such as FFA.
与眼底荧光血管造影（FFA）相比，评估光谱域光学相干断层扫描（SDOCT）在确定新生血管性年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）亚型方面的敏感性和特异性，以及两种检查方法之间的一致性。
这是一项回顾性观察研究。
我们评估并比较了100只接受雷珠单抗治疗的新生血管性AMD患眼的FFA和OCT上的CNV亚型。
与FFA相比，SDOCT在诊断CNV亚型方面显示出高敏感性（85.7-98.3%）和特异性（84.2-100%）。不同CNV亚型的受试者操作特征曲线下面积在0.9至0.93之间（p值<0.0001）。加权kappa统计显示两种检查方法之间的一致性接近完美，为0.85。
SDOCT是诊断新生血管性AMD中CNV亚型的可靠工具，无需像FFA这样的侵入性检查。
