荧光素眼底血管造影与频域光学相干断层扫描在鉴别新生血管性年龄相关性黄斑变性中膜亚型的相关性
Correlation of fundus fluorescein angiography and spectral-domain optical coherence tomography in identification of membrane subtypes in neovascular age-related macular degeneration.
作者信息
Mathew Raeba, Pefkianaki Maria, Kopsachilis Nickolaos, Brar Manpreet, Richardson Matthew, Sivaprasad Sobha
机构信息
Laser and Retinal Research Unit, Department of Ophthalmology, King's College Hospital, London, UK.
出版信息
Ophthalmologica. 2014;231(3):153-9. doi: 10.1159/000355091. Epub 2013 Nov 6.
AIMS
To assess the sensitivity and specificity of spectral-domain optical coherence tomography (SDOCT) for the determination of choroidal neovascularization (CNV) subtypes in neovascular age-related macular degeneration (AMD) compared to fundus fluorescein angiography (FFA) and also the agreement between the two procedures.
DESIGN
This was a retrospective, observational study.
METHODS
We evaluated and compared the CNV subtypes on FFA and OCT in 100 eyes initiated on ranibizumab for neovascular AMD.
RESULTS
SDOCT showed high sensitivity (85.7-98.3%) and specificity (84.2-100%) compared to FFA in the diagnosis of the CNV subtype. The area under the receiver-operating characteristic curve ranged from 0.9 to 0.93 (p value <0.0001) for the different CNV subtypes. Weighted kappa statistics showed a near-perfect agreement of 0.85 between the procedures.
CONCLUSION
SDOCT is a reliable tool for the diagnosis of CNV subtypes in neovascular AMD obviating the need for an invasive procedure such as FFA.
目的
与眼底荧光血管造影（FFA）相比，评估光谱域光学相干断层扫描（SDOCT）在确定新生血管性年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）亚型方面的敏感性和特异性，以及两种检查方法之间的一致性。
设计
这是一项回顾性观察研究。
方法
我们评估并比较了100只接受雷珠单抗治疗的新生血管性AMD患眼的FFA和OCT上的CNV亚型。
结果
与FFA相比，SDOCT在诊断CNV亚型方面显示出高敏感性（85.7-98.3%）和特异性（84.2-100%）。不同CNV亚型的受试者操作特征曲线下面积在0.9至0.93之间（p值<0.0001）。加权kappa统计显示两种检查方法之间的一致性接近完美，为0.85。
结论
SDOCT是诊断新生血管性AMD中CNV亚型的可靠工具，无需像FFA这样的侵入性检查。
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