O'Doherty Jim, Woods Elaine, Modde Lorenzo, Mackewn Jane
aKing's College London, PET Imaging Centre, St Thomas' Hospital, London, UK bTEMA Sinergie, Faenza, Italy.
Nucl Med Commun. 2014 Feb;35(2):151-9. doi: 10.1097/MNM.0000000000000027.
The current procedure at our centre for partitioning multidose vials of fluorine-18-fluorodeoxyglucose (F-FDG) is based on a manual method. To reduce extremity dose while reducing contamination risk, maintaining product sterility and improving the accuracy of injected activity, we recently purchased a new semiautomated partitioning system (μDDS-A). This work reports on the operating characteristics of the system and its validation for clinical use in terms of dispensing accuracy and extremity dose reduction.
A range of operators carried out 300 automated partitioning procedures by following a typical working-day setup. The accuracy of the activity resulting from system partitioning compared with true syringe activity was determined. We also determined the precision of system-determined activity when compared with user-requested activity. The cumulative finger dose for automated and manual partitioning techniques was measured at the fingertip using a digital dosimeter, recording the dose at different stages of the procedure.
The results of comparisons made between the final syringe activity measured by the system and the measurement of the true syringe activity independently of the system were within ±5% for 96.63% of syringes. Precision of the syringe activity provided by the system with respect to the user-requested activity was within ±10% for 96.96% of measurements. Average finger doses compared with a manual partitioning method showed a reduction of up to 80% when relying only on the system measurement of activity.
The μDDS-A reproducibly partitions a vial of F-FDG and offers a significant reduction in extremity dose to the operator of up to 80% in comparison with a manual partition technique.
我们中心目前对氟-18-氟脱氧葡萄糖（F-FDG）多剂量瓶进行分装的程序基于手工方法。为了在降低污染风险、保持产品无菌性并提高注射活度准确性的同时减少肢体剂量，我们最近购买了一种新型半自动分装系统（μDDS-A）。本文报告了该系统的操作特性及其在临床使用中的验证情况，包括分装准确性和肢体剂量降低情况。
一系列操作人员按照典型工作日设置进行了300次自动分装程序。确定了系统分装产生的活度与真实注射器活度相比的准确性。我们还确定了系统确定的活度与用户要求的活度相比的精密度。使用数字剂量计在指尖测量自动和手动分装技术的累积手指剂量，记录程序不同阶段的剂量。
系统测量的最终注射器活度与独立于系统的真实注射器活度测量结果之间的比较结果显示，96.63%的注射器在±5%以内。系统提供的注射器活度相对于用户要求的活度的精密度在96.96%的测量中在±10%以内。与手动分装方法相比，仅依靠系统活度测量时，平均手指剂量最多可降低80%。
μDDS-A可重复性地对F-FDG瓶进行分装，与手动分装技术相比，可为操作人员显著降低高达80%的肢体剂量。
