干扰素和白细胞介素2对小鼠肿瘤坏死因子内源性产生的启动作用。
Priming effect of interferons and interleukin 2 on endogenous production of tumor necrosis factor in mice.
作者信息
Satoh M, Shimada Y, Inagawa H, Minagawa H, Kajikawa T, Oshima H, Abe S, Yamazaki M, Mizuno D
出版信息
Jpn J Cancer Res. 1986 Apr;77(4):342-4.
The effects of interferons (IFNs) and interleukin 2 (IL 2) on endogenous production of tumor necrosis factor (TNF) were investigated in mice. Production of serum TNF was triggered by iv injection of OK-432 and tested by in vitro cytotoxicity assay. Injection of recombinant IFN-gamma with OK-432 and tested by in vitro cytotoxicity assay. Injection of recombinant IFN-gamma with OK-432 or of IFN-alpha/beta, recombinant IFN-beta, recombinant IFN-alpha A/D or recombinant IL 2 six hours before OK-432 enhanced TNF production about 10-fold, which indicated priming actions of these compounds in TNF production. These findings suggest that these compounds could also be used as priming agents for endogenous production of TNF in cancer patients.
在小鼠中研究了干扰素（IFN）和白细胞介素2（IL-2）对肿瘤坏死因子（TNF）内源性产生的影响。通过静脉注射OK-432触发血清TNF的产生，并通过体外细胞毒性试验进行检测。将重组IFN-γ与OK-432一起注射，并通过体外细胞毒性试验进行检测。在注射OK-432前6小时注射重组IFN-γ与OK-432，或注射IFN-α/β、重组IFN-β、重组IFN-αA/D或重组IL-2，可使TNF产生增加约10倍，这表明这些化合物在TNF产生中具有启动作用。这些发现提示，这些化合物也可作为癌症患者内源性产生TNF的启动剂。
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