Bergstrom R F, Fites A L, Lamb J W
Am J Hosp Pharm. 1975 Sep;32(9):887-8.
The stability and physical compatibility of tobramycin sulfate in commonly used intravenous fluids were evaluated; in addition, pH values were obtained on 1 mg/ml tobramycin solutions, and microbiological potencies were obtained on 1 mg/ml and 0.2 mg/ml concentrations for 24- and 48-hour periods at 25 C. Most solutions were stable for 48 hours at room temperature. However, it is recommended that solutions of tobramycin sulfate be discarded after 24 hours to minimize the potential for inadvertent introduction of microorganisms during manipulations in the hospital environment.
评估了硫酸妥布霉素在常用静脉输液中的稳定性和物理相容性；此外，还测定了1mg/ml妥布霉素溶液的pH值，并在25℃下测定了1mg/ml和0.2mg/ml浓度的溶液在24小时和48小时的微生物效价。大多数溶液在室温下48小时内稳定。然而，建议硫酸妥布霉素溶液在24小时后丢弃，以尽量减少在医院环境中操作期间意外引入微生物的可能性。
