O'Brien M J, Portnoff J B, Cohen E M
Am J Hosp Pharm. 1979 Jan;36(1):33-8.
The compatibility and stability of cefoxitin sodium in solution with a series of frequently used intravenous infusion fluids and injectable additives were studied. Cefoxitin sodium's stability in various solutions was measured by ultraviolet spectrophotometry, iodometry, thin-layer chromatography, high-pressure liquid chromatography, ion-exchange chromatography and microbiological assay. Cefoxitin sodium was shown to maintain 90% of its initial concentration in aqueous solution for 40 hours at room temperature (25 C) and about 30 days at 5 C. The stability of cefoxitin sodium in common i.v. infusion fluids was independent of the concentrations (1 mg/ml to 400 mg/ml) and containers used, and was retained after 30 weeks storage at -20 C. Similar stability patterns were demonstrated for cefoxitin sodium in protein hydrolysate solutions and multivitamin formulations. Cefoxitin sodium was chemically and visually compatible with amikacin sulfate, gentamicin sulfate, kanamycin sulfate and tobramycin sulfate when admixed with normal saline or 5% dextrose in water injections. Cefoxitin sodium (397 mg/ml) in 0.5% lidocaine hydrochloride was stable after 26 weeks of storage at -20 C. Sodium cefoxitin is compatible with a wide variety of commonly used infusion solutions. Its stability is independent of concentration or pH within the ranges studied, and of types of common containers.
研究了头孢西丁钠在溶液中与一系列常用静脉输液和注射用添加剂的配伍性和稳定性。采用紫外分光光度法、碘量法、薄层色谱法、高压液相色谱法、离子交换色谱法和微生物测定法测定头孢西丁钠在各种溶液中的稳定性。结果表明，头孢西丁钠在室温（25℃）的水溶液中40小时内可保持其初始浓度的90%，在5℃下约30天可保持稳定。头孢西丁钠在常用静脉输液中的稳定性与浓度（1mg/ml至400mg/ml）和所用容器无关，在-20℃储存30周后仍能保持稳定。头孢西丁钠在蛋白水解液和多种维生素制剂中也表现出类似的稳定性模式。当与生理盐水或5%葡萄糖注射液混合时，头孢西丁钠与硫酸阿米卡星、硫酸庆大霉素、硫酸卡那霉素和硫酸妥布霉素在化学和外观上是相容的。头孢西丁钠（397mg/ml）在0.5%盐酸利多卡因中于-20℃储存26周后仍保持稳定。头孢西丁钠与多种常用输液溶液相容。在所研究的浓度范围、pH值范围内以及常见容器类型中，其稳定性不受影响。
