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大鼠同种异体脾移植的形态学特征。同一供体-受体配对中的移植物排斥、接受或致死性移植物抗宿主病。

Morphologic features of spleen allografts in rats. Graft rejection, acceptance, or lethal graft-versus-host disease in the same donor-recipient pairing.

作者信息

Bitter-Suermann H, Herbertson B M

出版信息

Am J Pathol. 1975 Nov;81(2):283-303.

PMID:242220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032206/
Abstract

The structural changes in serial biopsies of spleen allografts in inbred histoincompatible rats are described. Three experimental procedures in the same donor-recipient pairing (PVG to AGUS) were employed and resulted in spleen graft rejection (Group I, no pretreatment), spleen graft acceptance (Group II, hosts pretreated with donor cells), and lethal GVH disease (Group III, donors pretreated with host cells). Striking features in the three groups were the variation of involvement of the periarterial lymphatic sheaths (PALS) shortly after grafting, and a substantial increase in hemopoiesis, particularly erythropoiesis, in the red pulp. The very "quiet" cellular reaction in the PALS of the host spleens in Group II corresponded with permanent graft acceptance. In Group III the previously sensitized allografts behaved rather like Group I host spleens and, by causing fatal GVH disease, demonstrated their immunologic superiority.

摘要

本文描述了近交系组织不相容大鼠同种异体脾移植系列活检中的结构变化。采用了同一供体-受体配对（从PVG到AGUS）的三种实验程序，结果分别是脾移植排斥（第一组，未预处理）、脾移植接受（第二组，宿主用供体细胞预处理）和致死性移植物抗宿主病（第三组，供体用宿主细胞预处理）。三组的显著特征是移植后不久动脉周围淋巴鞘（PALS）受累情况的变化，以及红髓中造血，尤其是红细胞生成的大量增加。第二组宿主脾脏PALS中非常“安静”的细胞反应与移植的永久接受相对应。在第三组中，先前致敏的同种异体移植物的表现与第一组宿主脾脏相当，并通过引发致命的移植物抗宿主病，显示出它们的免疫优势。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a90/2032206/210b0e7275e6/amjpathol00456-0051-a.jpg
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本文引用的文献

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SPLENIC HOMOTRANSPLANTATION.脾同种移植
Ann N Y Acad Sci. 1964 Nov 30;120:626-51. doi: 10.1111/j.1749-6632.1964.tb34757.x.
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The splenic homograft: its course in the unmodified and modified canine recipient.脾同种异体移植：其在未改良和改良犬受体中的进程。
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The homograft response to whole-organ transplantation of the canine spleen.犬脾脏全器官移植的同种异体移植反应。
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Spleen transplantation in the rat.大鼠脾脏移植
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Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats.正常大鼠淋巴组织和胸导管淋巴中骨髓源性和胸腺源性小淋巴细胞的鉴定。
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9
The effect of prior administration of donor strain blood or blood constituents on the survival of cardiac allografts in rats.预先给予供体品系血液或血液成分对大鼠心脏同种异体移植物存活的影响。
Transplantation. 1971 Jul;12(1):57-60. doi: 10.1097/00007890-197107000-00010.
10
Renal transplantation in the inbred rat. 13. Modification of rejection by active immunization with bone marrow cells.近交系大鼠的肾移植。13. 用骨髓细胞主动免疫对排斥反应的改良。
Transplantation. 1970 Jan;9(1):30-8.