Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
Anticancer Res. 2013 Nov;33(11):5031-41.
A meta-analysis was conducted to evaluate and compare the short- and long-term outcomes of laparoscopic and conventional open surgery for gastric gastrointestinal stromal tumors (GISTs).
We searched MEDLINE, EMBASE, Science Citation Index, and the Cochrane Controlled Trial Register for relevant articles published between 2000 and July 2013 by using the search terms "laparoscopic", "laparoscopy-assisted", "surgery", "gastrointestinal tumor", "GIST" and "gastric".
We identified 12 articles reporting results that compared laparoscopic surgery with open surgery for gastric GISTs. Our meta-analysis included 644 patients with GISTs; 312 had undergone laparoscopic surgery, and 332 had undergone open surgery. In the short-term period, 14 outcome variables were examined. In the long-term period, six oncological variables were analyzed. Laparoscopic surgery for gastric GIST was associated with a reduction in intraoperative blood loss, shorter period to flatus, earlier resumption of oral intake, and shorter duration of hospital stay over the short-term, and with a significantly lower rate of overall recurrence, metastatic recurrence and local recurrence in the long-term compared to open surgery.
Laparoscopic surgery may be an acceptable surgical treatment option compared to open surgery for gastric GIST.
本荟萃分析旨在评估并比较腹腔镜与传统开腹手术治疗胃胃肠间质瘤（GIST）的短期和长期疗效。
我们检索了 2000 年至 2013 年 7 月期间 MEDLINE、EMBASE、科学引文索引和 Cochrane 对照试验注册库中使用“laparoscopic”、“laparoscopy-assisted”、“surgery”、“gastrointestinal tumor”、“GIST”和“gastric”等检索词发表的相关文章。
我们共确定了 12 项比较腹腔镜手术与开腹手术治疗胃 GIST 的研究。我们的荟萃分析纳入了 644 例 GIST 患者，其中 312 例行腹腔镜手术，332 例行开腹手术。短期疗效评估了 14 个结局变量，长期疗效分析了 6 个肿瘤学变量。与开腹手术相比，腹腔镜手术治疗胃 GIST 术中出血量较少、肛门排气时间更早、开始经口进食时间更早、住院时间更短，且长期总复发率、远处转移复发率和局部复发率更低。
与开腹手术相比，腹腔镜手术可能是一种可接受的胃 GIST 外科治疗选择。
