• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

年龄相关的人类中枢听觉功能不对称性降低：1H 磁共振波谱研究。

Age-associated reduction of asymmetry in human central auditory function: a 1H-magnetic resonance spectroscopy study.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Fuzhou General Hospital of Nanjing Command, PLA, 156 Xihuan Bei Road, Fuzhou 350025, China ; Department of Otolaryngology-Head and Neck Surgery, Dongfang Hospital, Fujian Medical University, Fuzhou 350001, China.

出版信息

Neural Plast. 2013;2013:735290. doi: 10.1155/2013/735290. Epub 2013 Oct 9.

DOI:10.1155/2013/735290
PMID:24222864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3809597/
Abstract

The aim of this study was to investigate the effects of age on hemispheric asymmetry in the auditory cortex after pure tone stimulation. Ten young and 8 older healthy volunteers took part in this study. Two-dimensional multivoxel 1H-magnetic resonance spectroscopy scans were performed before and after stimulation. The ratios of N-acetylaspartate (NAA), glutamate/glutamine (Glx), and γ -amino butyric acid (GABA) to creatine (Cr) were determined and compared between the two groups. The distribution of metabolites between the left and right auditory cortex was also determined. Before stimulation, left and right side NAA/Cr and right side GABA/Cr were significantly lower, whereas right side Glx/Cr was significantly higher in the older group compared with the young group. After stimulation, left and right side NAA/Cr and GABA/Cr were significantly lower, whereas left side Glx/Cr was significantly higher in the older group compared with the young group. There was obvious asymmetry in right side Glx/Cr and left side GABA/Cr after stimulation in young group, but not in older group. In summary, there is marked hemispheric asymmetry in auditory cortical metabolites following pure tone stimulation in young, but not older adults. This reduced asymmetry in older adults may at least in part underlie the speech perception difficulties/presbycusis experienced by aging adults.

摘要

本研究旨在探讨纯音刺激后听觉皮层半球间不对称性随年龄变化的情况。10 名年轻志愿者和 8 名老年志愿者参加了本研究。在刺激前后进行二维多体 1H 磁共振波谱扫描。测定 N-乙酰天冬氨酸（NAA）、谷氨酸/谷氨酰胺（Glx）和γ-氨基丁酸（GABA）与肌酸（Cr）的比值，并比较两组之间的差异。还确定了代谢物在左右听觉皮层之间的分布情况。刺激前，老年组左侧和右侧 NAA/Cr 以及右侧 GABA/Cr 明显低于年轻组，而右侧 Glx/Cr 明显高于年轻组。刺激后，老年组左侧和右侧 NAA/Cr 以及 GABA/Cr 明显低于年轻组，而左侧 Glx/Cr 明显高于年轻组。在年轻组中，刺激后右侧 Glx/Cr 和左侧 GABA/Cr 明显不对称，但在老年组中则没有。总之，在年轻成年人中，纯音刺激后听觉皮层代谢物存在明显的半球间不对称性，但在老年成年人中则没有。这种老年人中对称性的降低至少部分解释了老年人在言语感知方面的困难/老年性聋。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/b26385ebbbc6/NP2013-735290.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/ba15797cee36/NP2013-735290.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/39a10a56e440/NP2013-735290.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/6f1f020d5189/NP2013-735290.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/b26385ebbbc6/NP2013-735290.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/ba15797cee36/NP2013-735290.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/39a10a56e440/NP2013-735290.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/6f1f020d5189/NP2013-735290.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e5c/3809597/b26385ebbbc6/NP2013-735290.004.jpg

相似文献

1
Age-associated reduction of asymmetry in human central auditory function: a 1H-magnetic resonance spectroscopy study.年龄相关的人类中枢听觉功能不对称性降低：1H 磁共振波谱研究。
Neural Plast. 2013;2013:735290. doi: 10.1155/2013/735290. Epub 2013 Oct 9.
2
[(1)H-MRS study of auditory cortex in patients with presbycusis].(1) 老年性聋患者听觉皮层的氢质子磁共振波谱研究
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Oct;47(10):852-5.
3
Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.磁共振波谱显示 presbycusis 中听皮层的代谢变化。
Exp Gerontol. 2013 Aug;48(8):795-800. doi: 10.1016/j.exger.2013.04.012. Epub 2013 May 4.
4
Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment.正常老年人及认知障碍患者大脑中的谷氨酸-谷氨酰胺和γ-氨基丁酸
Eur Radiol. 2017 Jul;27(7):2698-2705. doi: 10.1007/s00330-016-4669-8. Epub 2016 Dec 13.
5
Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy.编辑磁共振波谱显示老年聋患者听觉GABA⁺浓度降低。
Neuroimage. 2015 Feb 1;106:311-6. doi: 10.1016/j.neuroimage.2014.11.023. Epub 2014 Nov 15.
6
Total GABA level in human auditory cortex is associated with speech-in-noise understanding in older age.人类听觉皮层中的总 GABA 水平与老年人群在噪声环境下的言语理解能力相关。
Neuroimage. 2021 Jan 15;225:117474. doi: 10.1016/j.neuroimage.2020.117474. Epub 2020 Oct 21.
7
Functional studies of the human auditory pathway after monaural stimulation with pure tones. Establishing a normal database.单耳纯音刺激后人听觉通路的功能研究。建立正常数据库。
Acta Otolaryngol. 2005 May;125(5):513-9. doi: 10.1080/00016480510026250.
8
Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: a (1)H-MRS study.孤独症患者及一级亲属听觉皮层谷氨酸浓度升高：一项（1）H-MRS 研究。
Autism Res. 2013 Feb;6(1):1-10. doi: 10.1002/aur.1260. Epub 2012 Nov 16.
9
Proton magnetic resonance spectroscopy (1H MRS) in schizophrenia: investigation of the right and left hippocampus, thalamus, and prefrontal cortex.精神分裂症中的质子磁共振波谱（1H MRS）：右侧和左侧海马体、丘脑及前额叶皮质的研究
Schizophr Bull. 2002;28(2):329-39. doi: 10.1093/oxfordjournals.schbul.a006942.
10
In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsy.人体部分性癫痫中谷氨酰胺+谷氨酸（Glx）和N-乙酰天门冬氨酸（NAA）水平的体内测量。
Acta Neurol Scand. 2000 Sep;102(3):179-88. doi: 10.1034/j.1600-0404.2000.102003179.x.

引用本文的文献

1
Asymmetries and hemispheric interaction in the auditory system of elderly people.老年人听觉系统中的不对称性与半球间相互作用。
Front Neuroimaging. 2024 Jan 3;2:1320989. doi: 10.3389/fnimg.2023.1320989. eCollection 2023.
2
Auditory brainstem response asymmetries in older adults: An exploratory study using click and speech stimuli.老年人听觉脑干反应的不对称性：使用点击和语音刺激的探索性研究。
PLoS One. 2021 May 7;16(5):e0251287. doi: 10.1371/journal.pone.0251287. eCollection 2021.
3
Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels.

本文引用的文献

1
[Assessment of two central auditory tests in elderly patients without hearing complaints].[对无听力主诉老年患者的两项中枢听觉测试评估]
Braz J Otorhinolaryngol. 2011 Jan-Feb;77(1):24-32. doi: 10.1590/s1808-86942011000100005.
2
Aging and lateralization of the rat brain on a biochemical level.大鼠脑在生化水平上的衰老和偏侧化。
Neurochem Res. 2010 Aug;35(8):1138-46. doi: 10.1007/s11064-010-0165-8. Epub 2010 Apr 6.
3
A multisensory cortical network for understanding speech in noise.一个用于理解噪声中语音的多感官皮层网络。
听觉皮层的神经独特性随年龄增长而下降，与听觉 GABA 水平相关。
Neuroimage. 2019 Nov 1;201:116033. doi: 10.1016/j.neuroimage.2019.116033. Epub 2019 Jul 18.
4
Aging Affects Neural Synchronization to Speech-Related Acoustic Modulations.衰老影响对与言语相关的声学调制的神经同步。
Front Aging Neurosci. 2016 Jun 15;8:133. doi: 10.3389/fnagi.2016.00133. eCollection 2016.
J Cogn Neurosci. 2009 Sep;21(9):1790-805. doi: 10.1162/jocn.2009.21118.
4
Recent advances in magnetic resonance neurospectroscopy.磁共振神经光谱学的最新进展。
Neurotherapeutics. 2007 Jul;4(3):330-45. doi: 10.1016/j.nurt.2007.04.009.
5
The effect of aging on event-related potentials and behavioral responses: comparison of tonal, phonologic and semantic targets.衰老对事件相关电位及行为反应的影响：音调、语音和语义目标的比较。
Clin Neurophysiol. 2006 Sep;117(9):1974-89. doi: 10.1016/j.clinph.2006.05.024. Epub 2006 Jul 20.
6
Hemispheric asymmetry for spectral and temporal processing in the human antero-lateral auditory belt cortex.人类前外侧听觉带皮层中频谱和时间处理的半球不对称性。
Eur J Neurosci. 2005 Sep;22(6):1521-8. doi: 10.1111/j.1460-9568.2005.04315.x.
7
Lateralization, connectivity and plasticity in the human central auditory system.人类中枢听觉系统中的偏侧化、连接性与可塑性
Neuroimage. 2005 Nov 1;28(2):490-9. doi: 10.1016/j.neuroimage.2005.06.024. Epub 2005 Jul 26.
8
Principles and clinical applications of auditory evoked potentials in the geriatric population.老年人群听觉诱发电位的原理及临床应用
Phys Med Rehabil Clin N Am. 2004 Feb;15(1):235-50, viii-ix. doi: 10.1016/s1047-9651(03)00099-8.
9
Mapping brain asymmetry.绘制大脑不对称性图谱。
Nat Rev Neurosci. 2003 Jan;4(1):37-48. doi: 10.1038/nrn1009.
10
Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction.半球不对称与衰老：右半球衰退还是不对称性降低。
Neurosci Biobehav Rev. 2002 Nov;26(7):819-25. doi: 10.1016/s0149-7634(02)00068-4.