磁共振神经光谱学的最新进展。
Recent advances in magnetic resonance neurospectroscopy.
作者信息
Rosen Yael, Lenkinski Robert E
机构信息
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
出版信息
Neurotherapeutics. 2007 Jul;4(3):330-45. doi: 10.1016/j.nurt.2007.04.009.
Over the past two decades, proton magnetic resonance spectroscopy (proton MRS) of the brain has made the transition from research tool to a clinically useful modality. In this review, we first describe the localization methods currently used in MRS studies of the brain and discuss the technical and practical factors that determine the applicability of the methods to particular clinical studies. We also describe each of the resonances detected by localized solvent-suppressed proton MRS of the brain and discuss the metabolic and biochemical information that can be derived from an analysis of their concentrations. We discuss spectral quantitation and summarize the reproducibility of both single-voxel and multivoxel methods at 1.5 and 3-4 T. We have selected three clinical neurologic applications in which there has been a consensus as to the diagnostic value of MRS and summarize the information relevant to clinical applications. Finally, we speculate about some of the potential technical developments, either in progress or in the future, that may lead to improvements in the performance of proton MRS.
在过去二十年中，脑部质子磁共振波谱（质子MRS）已从研究工具转变为一种临床实用的检查方式。在本综述中，我们首先描述目前在脑部MRS研究中使用的定位方法，并讨论决定这些方法在特定临床研究中适用性的技术和实际因素。我们还描述了通过脑部局部溶剂抑制质子MRS检测到的每种共振，并讨论了可从其浓度分析中得出的代谢和生化信息。我们讨论光谱定量，并总结1.5T和3 - 4T下单体素和多体素方法的可重复性。我们选择了三个临床神经学应用，在这些应用中，关于MRS的诊断价值已达成共识，并总结了与临床应用相关的信息。最后，我们推测了一些正在进行或未来可能导致质子MRS性能改善的潜在技术发展。
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