Alappan Narendrakumar, Marak Creticus P, Chopra Amit, Joy Parijat S, Dorokhova Olena, Guddati Achuta K
Division of Pulmonary and Critical Care Medicine, Montefiore Hospital, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Case Rep Oncol Med. 2013;2013:129813. doi: 10.1155/2013/129813. Epub 2013 Oct 7.
Renal medullary cancer is a rare malignancy almost exclusively seen in young patients of African ethnicity. These patients often present with the cardinal symptoms of hematuria, flank pain, and an abdominal mass, and this malignancy has been associated with patients carrying sickle cell trait. It is estimated that 300 million people worldwide carry sickle cell trait, and the presence of hematuria in these patients should be treated as a harbinger of a possible malignancy. Notably, this tumor mostly develops on the right side of the body. Patients often present with it at an advanced stage and the prognosis is poor. Therefore, a high index of suspicion in a patient of African descent presenting with a right sided abdominal mass and hematuria may assist in an early diagnosis. Current chemotherapy options are very limited, and early detection may provide a chance for surgical resection. It may also provide a bigger time frame for the initiation of novel chemotherapy regimens in patients who fail current chemotherapy regimens.
肾髓质癌是一种罕见的恶性肿瘤，几乎仅见于非洲裔年轻患者。这些患者常表现出血尿、胁腹痛和腹部肿块等主要症状，且这种恶性肿瘤与携带镰状细胞性状的患者有关。据估计，全球有3亿人携带镰状细胞性状，这些患者出现血尿应被视为可能发生恶性肿瘤的先兆。值得注意的是，这种肿瘤大多发生在身体右侧。患者常以晚期状态就诊，预后较差。因此，对出现右侧腹部肿块和血尿的非洲裔患者高度怀疑可能有助于早期诊断。目前的化疗选择非常有限，早期检测可能为手术切除提供机会。对于当前化疗方案失败的患者，早期检测还可能为启动新的化疗方案提供更长的时间框架。
