Columbia University College of Physicians and Surgeons.
Department of Ophthalmology, Columbia University Medical Center.
Ophthalmic Plast Reconstr Surg. 2019 Nov/Dec;35(6):e149-e151. doi: 10.1097/IOP.0000000000001478.
A 22-year-old Hispanic man with sickle cell trait presented with blurred vision, double vision, and pain with OD movement. MRI demonstrated an extra-axial mass centered around the temporal bone with extension into the middle cranial fossa and lateral aspect of the extra-conal right orbit, and mass effect on the lateral rectus muscle. Biopsy of the lesion was consistent with renal medullary carcinoma. CT chest/abdomen/pelvis confirmed a primary tumor in the right kidney. No additional metastases were found. Renal medullary carcinoma is a rare, highly aggressive malignancy, which almost exclusively affects young men of African descent with sickle cell trait or sickle cell disease. The authors present the second confirmed case of renal medullary carcinoma metastatic to the orbit, with ocular symptoms prior the typical presenting symptoms of flank pain and hematuria.Renal medullary carcinoma is a highly aggressive malignancy, most commonly seen in African American patients with sickle cell disease. Involvement of the orbit is rare and visual symptoms may precede systemic diagnosis.
一位 22 岁的西班牙裔男性，携镰状细胞特征，表现为视力模糊、复视和右眼运动时疼痛。MRI 显示颞骨周围有一个颅外肿块，延伸至中颅窝和右侧眶外侧面，外侧直肌有肿块效应。病变活检符合肾髓质癌。胸部/腹部/骨盆 CT 证实右肾有原发性肿瘤。未发现其他转移灶。肾髓质癌是一种罕见的、高度侵袭性的恶性肿瘤，几乎只影响携带镰状细胞特征或镰状细胞病的年轻非洲裔男性。作者报告了第二例肾髓质癌转移至眼眶的确诊病例，眼部症状先于典型的腰痛和血尿出现。肾髓质癌是一种高度侵袭性的恶性肿瘤，最常见于患有镰状细胞病的非裔美国患者。眼眶受累很少见，且视力症状可能先于全身诊断。
