Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Prostate Int. 2013;1(1):3-9. doi: 10.12954/PI.12011. Epub 2012 Dec 13.
MicroRNAs (miRNAs) are made up of -22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic markers for various cancers. Also, alterations of miRNAs in cancer tissues have been associated with clinicopathological parameters. Along with circulating miRNAs, tissue miRNAs have shown promise as markers that can predict cancer recurrence and/or the potential for survival of cancer patients. Additionally, some miRNAs have therapeutic potential. In this review, we discuss and assess the usefulness of tissue-derived and circulating miRNAs for the diagnosis and prognosis of prostate cancer.
微小 RNA（miRNA）由 22 个内源性核苷酸组成，是小的非编码 RNA，通过降解或抑制靶 miRNA，在转录后水平上对基因表达进行重要调节。miRNA 表达谱可用于检测各种癌症的诊断和预后标志物。此外，癌症组织中 miRNA 的改变与临床病理参数有关。与循环 miRNA 一起，组织 miRNA 已显示出作为预测癌症复发和/或癌症患者生存潜力的标志物的潜力。此外，一些 miRNA 具有治疗潜力。在这篇综述中，我们讨论并评估了组织来源和循环 miRNA 用于前列腺癌诊断和预后的有用性。
