Black Lucinda J, Jacoby Peter, Allen Karina L, Trapp Gina S, Hart Prue H, Byrne Susan M, Mori Trevor A, Beilin Lawrence J, Oddy Wendy H
1Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia.
Aust N Z J Psychiatry. 2014 May;48(5):464-71. doi: 10.1177/0004867413512383. Epub 2013 Nov 13.
Results from studies examining associations between serum 25-hydroxyvitamin D (25(OH)D) concentrations and depressive symptoms are equivocal. We investigated the relationship between serum 25(OH)D concentrations and symptoms of depression, anxiety and stress in a cross-sectional analysis of a population-based sample of young adults participating in the Western Australian Pregnancy Cohort (Raine) Study.
Participants provided a blood sample at the 20-year follow-up (March 2010-April 2012) for the measurement of serum 25(OH)D concentrations. Mental health symptoms were assessed using the 21-item Depression Anxiety Stress Scales (DASS-21). Associations between serum 25(OH)D concentrations and total DASS-21 scores and subscale scores of depression, anxiety and stress were explored in males and females using negative binomial regression, adjusting for age, race, body mass index (BMI) and physical activity (n=735). Models examining subscale scores were also adjusted for the other subscale scores.
After adjusting for confounders, an increase in serum 25(OH)D concentrations of 10 nmol/L decreased total DASS-21 scores in males by 9% (rate ratio (RR) 0.91; 95%CI 0.87,0.95; p<0.001) and depression subscale scores in males by 8% (RR 0.92; 95%CI 0.87,0.96; p=0.001). However, in adjusted models there were no significant associations between serum 25(OH)D concentrations and symptoms of anxiety and stress in males. There were no significant associations between serum 25(OH)D concentrations and symptoms of depression, anxiety and stress in females.
We found an association between serum 25(OH)D concentrations and symptoms of depression, but not anxiety and stress, in males. Randomised controlled trials are necessary to determine any benefit of vitamin D supplementation in the prevention and treatment of depressive symptoms in young adults.
关于血清25-羟维生素D（25(OH)D）浓度与抑郁症状之间关联的研究结果并不明确。我们在参与西澳大利亚妊娠队列（Raine）研究的基于人群的年轻成年人样本的横断面分析中，调查了血清25(OH)D浓度与抑郁、焦虑和压力症状之间的关系。
参与者在20年随访期（2010年3月至2012年4月）提供血样，用于测量血清25(OH)D浓度。使用21项抑郁焦虑压力量表（DASS-21）评估心理健康症状。采用负二项回归分析男性和女性血清25(OH)D浓度与DASS-21总分以及抑郁、焦虑和压力分量表得分之间的关联，并对年龄、种族、体重指数（BMI）和身体活动进行校正（n = 735）。检验分量表得分的模型也对其他分量表得分进行了校正。
校正混杂因素后，血清25(OH)D浓度每增加10 nmol/L，男性DASS-21总分降低9%（率比（RR）0.91；95%置信区间0.87,0.95；p<0.001），男性抑郁分量表得分降低8%（RR 0.92；95%置信区间0.87,0.96；p = 0.001）。然而，在校正模型中，男性血清25(OH)D浓度与焦虑和压力症状之间无显著关联。女性血清25(OH)D浓度与抑郁、焦虑和压力症状之间无显著关联。
我们发现男性血清25(OH)D浓度与抑郁症状之间存在关联，但与焦虑和压力症状无关。有必要进行随机对照试验，以确定补充维生素D在预防和治疗年轻成年人抑郁症状方面的任何益处。
