von der Maase H, Overgaard J, Vaeth M
Radiother Oncol. 1986 Mar;5(3):245-57. doi: 10.1016/s0167-8140(86)80054-8.
The effect of adriamycin (ADM), bleomycin (BLM), cyclophosphamide (CTX), 5-fluorouracil (5-FU), methotrexate (MTX), mitomycin C (MM-C) and cis-diamminedichloroplatinum(II) (cis-DDP) on the radiation-induced lung damage in mice was assessed by the ventilation rate (VR) and the lethality. Single drug doses were administered 15 min before graded single doses of irradiation and at different intervals from 28 days before to 28 days after fixed radiation doses. ADM, BLM and CTX administered 15 min before irradiation enhanced the radiation response with dose effect factors (DEF) of 1.46, 1.56 and 2.35, respectively. The effect of MM-C presented a complex picture. The drug had no effect at administration 15 min before 14-20 Gy, but enhanced the radiation response if given 15 min before 6-12 Gy (DEF = 1.57). The radiation-modifying effect of ADM, BLM, CTX and MM-C was most pronounced when the drugs were given 15 min before irradiation. The effect of ADM was present when administered from 7 days before to 7 days after irradiation. BLM and CTX enhanced the radiation response at administration from 24 h before to 3 days after irradiation, and the effect of MM-C was observed when the drug was given from 24 h before to 24 h after irradiation. 5-FU, MTX and cis-DDP had no effect on the radiation response at any of the investigated intervals.
通过通气率（VR）和致死率评估阿霉素（ADM）、博来霉素（BLM）、环磷酰胺（CTX）、5-氟尿嘧啶（5-FU）、甲氨蝶呤（MTX）、丝裂霉素C（MM-C）和顺二氯二氨铂（II）（顺铂）对小鼠辐射诱导肺损伤的影响。在分次给予分级单剂量辐射前15分钟以及在固定辐射剂量前28天至后28天的不同时间间隔给予单药剂量。辐射前15分钟给予的ADM、BLM和CTX增强了辐射反应，剂量效应因子（DEF）分别为1.46、1.56和2.35。MM-C的作用呈现出复杂的情况。该药物在14 - 20 Gy辐射前15分钟给药时无作用，但在6 - 12 Gy辐射前15分钟给药则增强了辐射反应（DEF = 1.57）。当在辐射前15分钟给予ADM、BLM、CTX和MM-C时，其辐射修饰作用最为明显。ADM在辐射前7天至后7天给药时均有作用。BLM和CTX在辐射前24小时至后3天给药时增强了辐射反应，MM-C在辐射前24小时至后24小时给药时观察到有作用。5-FU、MTX和顺铂在任何研究的时间间隔对辐射反应均无影响。
