von der Maase H
Br J Radiol. 1984 Aug;57(680):697-707. doi: 10.1259/0007-1285-57-680-697.
The interactions of seven cancer chemotherapeutic drugs and radiation in normal skin were studied using the mouse foot skin scoring system. Single drug doses were administered 15 min before graded single doses of irradiation or at different intervals before and after a fixed radiation dose. Adriamycin (ADM), bleomycin (BLM), methotrexate (MTX), mitomycin-C (MM-C), and cis-platinum (cis-DDP) all significantly enhanced the radiation-induced skin reactions. The dose-effect factors (DEF) for these drugs ranged from 1.07 to 1.11. Cyclophosphamide (CTX) had a radioprotective effect (DEF 0.90), whereas 5-fluorouracil (5-FU) had no effect (DEF 1.00). The effect of ADM was present at administration from 6 h before to 2 min after irradiation, and the effect of BLM from 24 h before to 4 h after irradiation. The radioprotective effect of CTX and the enhanced effect of MM-C were only present on administration 15 min before and 2 min after irradiation. MTX and cis-DDP enhanced the skin reactions only when given before irradiation.
使用小鼠足部皮肤评分系统研究了七种癌症化疗药物与辐射对正常皮肤的相互作用。在分级单次辐射剂量前15分钟给予单药剂量，或在固定辐射剂量前后的不同时间间隔给予。阿霉素（ADM）、博来霉素（BLM）、甲氨蝶呤（MTX）、丝裂霉素-C（MM-C）和顺铂（顺-DDP）均显著增强辐射诱导的皮肤反应。这些药物的剂量效应因子（DEF）范围为1.07至1.11。环磷酰胺（CTX）具有辐射防护作用（DEF 0.90），而5-氟尿嘧啶（5-FU）无作用（DEF 1.00）。ADM在照射前6小时至照射后2分钟给药时均有作用，BLM在照射前24小时至照射后4小时有作用。CTX的辐射防护作用和MM-C的增强作用仅在照射前15分钟和照射后2分钟给药时出现。MTX和顺-DDP仅在照射前给药时增强皮肤反应。
