Katz N, Adir Y, Etzioni T, Kurtz E, Pillar G
Sleep Laboratory, Assuta Medical Services and Wolfson Hospital, 69710 Holon, Israel.
Sleep Disord. 2013;2013:840723. doi: 10.1155/2013/840723. Epub 2013 Oct 8.
Compliance with CPAP is the major limiting factor in treating patients with OSA. The novel SomnuSeal mask is an oral self-adaptable mask located between the teeth and the lips ensuring that there are no air leaks or skin abrasions. Fifty patients with AHI > 20, who failed previous CPAP trials, were asked to sleep with the mask for one month. In all patients, the mask was connected to an AutoPAP machine with a heated humidifier. Efficacy, convenience, and compliance (average usage for 4 or more hours per night) were monitored. Fifty patients (41 m and 9 f, mean age 57 ± 12 years, BMI 33.6 ± 4.9 kg/m(2), and AHI 47 ± 23/h) participated. Eleven were classified as compliant (average mask usage of 26 nights, 4.7 hours per night), five were only partially compliant (average usage of 13 nights, 2.9 hours per night), and 34 could not comply with it. In all patients who slept with it, the efficacy (assessed by residual AHI derived from the CPAP device) was good with an AHI of less than 8/hour. Interestingly, the required optimal pressure decreased from an average of 9.3 cmH2O to 4.6 cmH2O. The SomnuSeal oral interface is effective and may result in converting noncompliant untreated patients with OSA into well-treated ones.
持续气道正压通气（CPAP）的依从性是治疗阻塞性睡眠呼吸暂停（OSA）患者的主要限制因素。新型SomnuSeal面罩是一种位于牙齿和嘴唇之间的口腔自适应面罩，可确保无空气泄漏或皮肤擦伤。五十名平均每小时呼吸暂停低通气指数（AHI）>20且先前CPAP试验失败的患者被要求佩戴该面罩睡眠一个月。所有患者的面罩均连接至配有加热加湿器的自动调压持续气道正压通气（AutoPAP）机。监测其疗效、便利性和依从性（每晚平均使用4小时或更长时间）。五十名患者（41名男性和9名女性，平均年龄57±12岁，体重指数33.6±4.9kg/m²，AHI为47±23次/小时）参与了研究。其中11名被归类为依从性良好（面罩平均使用26晚，每晚4.7小时），5名仅部分依从（平均使用13晚，每晚2.9小时），34名无法依从。在所有佩戴该面罩睡眠的患者中，疗效（通过CPAP设备得出的残余AHI评估）良好，AHI小于8次/小时。有趣的是，所需的最佳压力从平均9.3cmH₂O降至4.6cmH₂O。SomnuSeal口腔接口有效，可能会使未得到有效治疗的OSA不依从患者转变为得到良好治疗的患者。
