Wang Jian, Zou Wen, Liu Ying
AIDS Research Center, China Academy of Traditional Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(15):2504-6.
Current international anti-HIV drug efficacy evaluation criteria including CD4 cell count and viral load. Antiviral therapy has good effect in suppressing viral load, although there are many limitations. More and more researchers began to focus on Chinese medicine. A large number of clinical practice shows that Chinese herbal medicine is good at improving patient immune function, reducing symptoms and improving quality of life, but the efficacy of inhibiting viral load was not obvious, clinical manifestation, immunological and virological indicators index inconsistency how to explain? This article from the perspective of theory and literature review, pointing out the similarities and differences of efficacy action points of Chinese and Western medicine treatment of AIDS from three aspects, including immune function, viral load and symptoms to explore the relevance of them. This paper proposed that immune function improvement and viral load change is not a direct inverse relationship (ie, improve immunity, the virus must fall); immunity improve followed by symptom relief and improved quality of life is more common to be seen; long-term improvement of immune function may follow by stable virus or gradual decline; the analysis still need to be testified in large sample, prolonged clinical observation in the future.
目前国际上抗HIV药物疗效评估标准包括CD4细胞计数和病毒载量。抗病毒治疗在抑制病毒载量方面有良好效果，尽管存在诸多局限性。越来越多的研究者开始关注中医药。大量临床实践表明，中药善于提高患者免疫功能、减轻症状、改善生活质量，但抑制病毒载量的疗效不明显，临床表现、免疫学及病毒学指标不一致该如何解释？本文从理论和文献回顾的角度，从免疫功能、病毒载量和症状三个方面指出中西医治疗艾滋病疗效作用点的异同，以探讨它们之间的相关性。本文提出免疫功能改善与病毒载量变化并非直接呈反比关系（即提高免疫力，病毒载量就一定会下降）；免疫力提高后随之症状缓解、生活质量改善更为常见；免疫功能长期改善后可能随之病毒载量稳定或逐渐下降；该分析仍有待未来大样本、长时间的临床观察予以验证。
