Hoban B P, Collin H B
Am J Optom Physiol Opt. 1986 Apr;63(4):271-6. doi: 10.1097/00006324-198604000-00006.
Cauterization of the cornea results in emigration of neutrophils from the limbal blood vessels into the corneal tissue. Blood vessel proliferation follows, the stimulus for which is unknown. In this study, 0.1 M sodium salicylate drops administered topically to cauterized rat corneas over a 48-h period had an inhibitory effect on the migration of neutrophils from the limbal vessels 6 h after injury, but this was not maintained at 48 h. After 6 days of treatment, the salicylate had no effect on vessel growth into the cauterized rat cornea. Application of prednisolone disodium phosphate ointment to cauterized corneas also inhibited neutrophil migration at 6 h, but increased the extravascular neutrophils at 48 h. After 6 days of treatment, corneal blood vessel growth was significantly reduced. It was concluded that there is no consistent relation between the number of extravascular neutrophils at the corneal limbus and the extent of corneal blood vessel growth.
角膜烧灼会导致中性粒细胞从角膜缘血管迁移至角膜组织。随后会出现血管增生，但其刺激因素尚不清楚。在本研究中，在48小时内对烧灼后的大鼠角膜局部滴注0.1M水杨酸钠，在损伤后6小时对中性粒细胞从角膜缘血管的迁移有抑制作用，但在48小时时这种作用未持续。治疗6天后，水杨酸盐对烧灼后的大鼠角膜血管生长没有影响。将泼尼松龙磷酸二钠眼膏应用于烧灼后的角膜，在6小时时也抑制了中性粒细胞迁移，但在48小时时增加了血管外中性粒细胞。治疗6天后，角膜血管生长显著减少。得出的结论是，角膜缘血管外中性粒细胞的数量与角膜血管生长程度之间没有一致的关系。
