水杨酸盐对人体白细胞迁移的影响。
The effect of salicylate on human leucocyte migration.
作者信息
Kemp A S, Smith J
出版信息
Clin Exp Immunol. 1982 Jul;49(1):233-8.
The effect of sodium salicylate, at concentrations obtained in vivo, on the random migration and chemotactic response of neutrophils and monocytes was examined. Incubation of cells in vitro increased neutrophil migration but decreased monocyte migration. However, both neutrophil and monocyte migration were significantly increased when obtained from normal individuals after ingestion of sodium salicylate. Salicylate also partly reversed the inhibition of neutrophil migration produced by aggregated immunoglobulin bound to the filter substrate. These effects of salicylate on leucocyte function may contribute to the anti-inflammatory activity of the drug.
研究了体内所获浓度的水杨酸钠对中性粒细胞和单核细胞随机迁移及趋化反应的影响。体外培养细胞会增加中性粒细胞的迁移，但会减少单核细胞的迁移。然而，从正常个体摄入水杨酸钠后获取的中性粒细胞和单核细胞的迁移均显著增加。水杨酸盐还部分逆转了与滤膜底物结合的聚集免疫球蛋白对中性粒细胞迁移的抑制作用。水杨酸盐对白细胞功能的这些影响可能有助于该药物的抗炎活性。
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