通过将 ras 和 PI3' 激酶分开来杀死肿瘤。
Killing tumors by keeping ras and PI3' kinase apart.
机构信息
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
出版信息
Cancer Cell. 2013 Nov 11;24(5):562-3. doi: 10.1016/j.ccr.2013.10.015.
PMID:24229705
Abstract
Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110α interaction for full activation of PI3K and tumor maintenance.
摘要
Ras 蛋白通过直接与 p110 催化亚基结合来介导 PI3K 的激活。然而，这种相互作用发生的时间和地点尚不清楚。在本期《癌细胞》杂志中，Castellano 及其同事报道称，RAS 驱动的肺癌需要 Ras-p110α 相互作用才能完全激活 PI3K 并维持肿瘤生长。
Zotero 插件