Institute of Nanoscience of Aragon and Department of Chemical Engineering, University of Zaragoza, E-50018, Zaragoza, Spain.
Lab Chip. 2014 Jan 21;14(2):325-32. doi: 10.1039/c3lc50999k. Epub 2013 Nov 15.
An exquisite control of synthesis parameters is generally required in nanomaterial synthesis to guarantee consistency in the essential characteristics such as size and shape. On the other hand, reliable scaled-up production of nanomaterials is required in order to achieve the production rates required for emerging nanotechnology applications while delivering a consistent product with the intended characteristics, avoiding the traditional batch-to-batch deviations. The continuous production of nanomaterials is challenging because of the difficulties involved in translating the complexity of nanomaterial synthesis into on-line operations. In this regard, microfluidic platforms stand out over conventional batch reactors due to their superior performance, easy scalability and reliability. Here, a continuous, scaled-up synthesis of high quality plasmonic hollow gold nanoparticles is reported for the first time. Not only was the throughput significantly higher than in a batch reactor, but also the microfluidic system allowed the on-line implementation of two new stages in nanomaterial production: surface functionalization and sterilization.
在纳米材料合成中，通常需要对合成参数进行精确控制，以确保尺寸和形状等基本特征的一致性。另一方面，为了实现新兴纳米技术应用所需的生产速率，同时提供具有预期特性的一致产品，避免传统的批间偏差，需要可靠的纳米材料规模化生产。由于将纳米材料合成的复杂性转化为在线操作具有挑战性，因此连续生产纳米材料具有挑战性。在这方面，微流控平台由于其卓越的性能、易于扩展和可靠性而优于传统的分批式反应器。在这里，首次报道了高质量等离子体空心金纳米粒子的连续规模化合成。不仅通量比批式反应器显著提高，而且微流控系统还允许在线实施纳米材料生产的两个新阶段：表面功能化和杀菌。
