蛋白质突出区域中“连续”抗原决定簇的位置。
Location of 'continuous' antigenic determinants in the protruding regions of proteins.
作者信息
Thornton J M, Edwards M S, Taylor W R, Barlow D J
出版信息
EMBO J. 1986 Feb;5(2):409-13. doi: 10.1002/j.1460-2075.1986.tb04226.x.
Abstract
A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.
摘要
本文描述了一种简单的方法，可根据蛋白质的α-碳坐标从蛋白质的球状表面突出部分定位“抗原性”肽段。在肌红蛋白、溶菌酶和肌血球素中，发现蛋白质突出部分与实验确定的抗原性肽段之间存在良好的相关性。同时，对使用突出指数、迁移率、溶剂可及性和亲水性来预测最可能的抗原性肽段进行了比较。
相似文献
1
Location of 'continuous' antigenic determinants in the protruding regions of proteins.蛋白质突出区域中“连续”抗原决定簇的位置。
EMBO J. 1986 Feb;5(2):409-13. doi: 10.1002/j.1460-2075.1986.tb04226.x.
2
Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).蛋白质中的抗原决定簇与大探针（抗体结构域）可及的表面区域一致。
Proc Natl Acad Sci U S A. 1986 Jan;83(2):226-30. doi: 10.1073/pnas.83.2.226.
3
An assessment of prediction methods for locating continuous epitopes in proteins.蛋白质中连续表位定位预测方法的评估
Immunol Lett. 1988 Feb;17(2):95-107. doi: 10.1016/0165-2478(88)90076-4.
4
Correlation between segmental mobility and the location of antigenic determinants in proteins.蛋白质中片段流动性与抗原决定簇位置之间的相关性。
Nature. 1984;311(5982):123-6. doi: 10.1038/311123a0.
5
The atomic mobility component of protein antigenicity.蛋白质抗原性的原子迁移成分。
Annu Rev Immunol. 1985;3:501-35. doi: 10.1146/annurev.iy.03.040185.002441.
6
Continuous and discontinuous protein antigenic determinants.连续和不连续蛋白质抗原决定簇。
Nature. 1986;322(6081):747-8. doi: 10.1038/322747a0.
7
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.抗肽抗体的反应性是蛋白质中位点原子迁移率的函数。
Nature. 1984;312(5990):127-34. doi: 10.1038/312127a0.
8
Antigenicity of myohemerythrin.肌红蛋白的抗原性。
Science. 1987 Dec 11;238(4833):1584-6. doi: 10.1126/science.2446393.
9
Normal-mode dynamics as a tool for predicting antigenic sites on proteins.作为预测蛋白质上抗原位点工具的正常模式动力学
Prog Clin Biol Res. 1989;289:87-94.
10
Computer prediction of potential immunogenic determinants from protein amino acid sequence.基于蛋白质氨基酸序列的潜在免疫原性决定簇的计算机预测。
Anal Biochem. 1987 Aug 15;165(1):200-7. doi: 10.1016/0003-2697(87)90220-x.
引用本文的文献
1
Immunoinformatics method to design universal multi-epitope nanoparticle vaccine for TGEV S protein.用于设计针对猪传染性胃肠炎病毒S蛋白的通用多表位纳米颗粒疫苗的免疫信息学方法
Sci Rep. 2025 Mar 29;15(1):10931. doi: 10.1038/s41598-025-95602-w.
2
Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody.与2型自身免疫性多内分泌综合征相关自身抗体结合的GAD65的结构与动力学
Nat Commun. 2025 Mar 7;16(1):2275. doi: 10.1038/s41467-025-57492-4.
3
Exploring Bioinformatics Solutions for Improved Leishmaniasis Diagnostic Tools: A Review.探索生物信息学解决方案，以改进利什曼病诊断工具：综述。
Molecules. 2024 Nov 7;29(22):5259. doi: 10.3390/molecules29225259.
4
Development and use of machine learning algorithms in vaccine target selection.机器学习算法在疫苗靶点选择中的开发与应用。
NPJ Vaccines. 2024 Jan 20;9(1):15. doi: 10.1038/s41541-023-00795-8.
5
Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics.基于免疫信息学的SADS-CoV表位筛选与疫苗分子设计
Front Vet Sci. 2023 Mar 2;9:1080927. doi: 10.3389/fvets.2022.1080927. eCollection 2022.
6
B-cell epitope discovery: The first protein flexibility-based algorithm-Zika virus conserved epitope demonstration.B 细胞表位发现：首个基于蛋白质柔性的算法——寨卡病毒保守表位展示。
PLoS One. 2023 Mar 15;18(3):e0262321. doi: 10.1371/journal.pone.0262321. eCollection 2023.
7
Recent trends in next generation immunoinformatics harnessed for universal coronavirus vaccine design.近年来，下一代免疫信息学的发展趋势被用于通用冠状病毒疫苗的设计。
Pathog Glob Health. 2023 Mar;117(2):134-151. doi: 10.1080/20477724.2022.2072456. Epub 2022 May 12.
8
A Systematic Immuno-Informatic Approach to Design a Multiepitope-Based Vaccine Against Emerging Multiple Drug Resistant .一种基于系统免疫信息学方法设计针对新出现的多重耐药性的多表位疫苗
Front Immunol. 2022 Mar 14;13:768569. doi: 10.3389/fimmu.2022.768569. eCollection 2022.
9
In silico construction of a multiepitope Zika virus vaccine using immunoinformatics tools.利用免疫信息学工具构建 Zika 病毒多表位疫苗的计算机模型。
Sci Rep. 2022 Jan 7;12(1):53. doi: 10.1038/s41598-021-03990-6.
10
Immunoinformatic Study of Recombinant LigA/BCon1-5 Antigen and Evaluation of Its Diagnostic Potential in Primary and Secondary Binding Tests for Serodiagnosis of Porcine Leptospirosis.重组LigA/BCon1-5抗原的免疫信息学研究及其在猪钩端螺旋体病血清学诊断的初次和二次结合试验中的诊断潜力评估
Pathogens. 2021 Aug 26;10(9):1082. doi: 10.3390/pathogens10091082.
本文引用的文献
1
Amino and carboxy-terminal regions in globular proteins.球状蛋白质中的氨基末端和羧基末端区域。
J Mol Biol. 1983 Jun 25;167(2):443-60. doi: 10.1016/s0022-2836(83)80344-1.
2
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.蛋白质二级结构词典：氢键和几何特征的模式识别
Biopolymers. 1983 Dec;22(12):2577-637. doi: 10.1002/bip.360221211.
3
Structural basis of antibody function.抗体功能的结构基础。
Annu Rev Immunol. 1983;1:87-117. doi: 10.1146/annurev.iy.01.040183.000511.
4
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.抗肽抗体的反应性是蛋白质中位点原子迁移率的函数。
Nature. 1984;312(5990):127-34. doi: 10.1038/312127a0.
5
Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites.蛋白质的抗原结构。其测定揭示了免疫识别的重要方面，并产生了合成模拟蛋白质结合位点的策略。
Eur J Biochem. 1984 Nov 15;145(1):1-20. doi: 10.1111/j.1432-1033.1984.tb08516.x.
6
Correlation between segmental mobility and the location of antigenic determinants in proteins.蛋白质中片段流动性与抗原决定簇位置之间的相关性。
Nature. 1984;311(5982):123-6. doi: 10.1038/311123a0.
7
How antigenic are antigenic peptides?抗原肽的抗原性如何？
Biopolymers. 1983 Jan;22(1):425-40. doi: 10.1002/bip.360220156.
8
Antibodies with specificities to preselected protein regions evoked by free synthetic peptides representing protein antigenic sites or other surface locations: demonstration with myoglobin.针对由代表蛋白质抗原位点或其他表面位置的游离合成肽引发的预选蛋白质区域具有特异性的抗体：以肌红蛋白为例的证明。
Mol Immunol. 1983 May;20(5):567-70. doi: 10.1016/0161-5890(83)90096-2.
9
Prediction of protein antigenic determinants from amino acid sequences.从氨基酸序列预测蛋白质抗原决定簇。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3824-8. doi: 10.1073/pnas.78.6.3824.
10
The effect of a single amino acid substitution on the antigenic specificity of the loop region of lysozyme.单个氨基酸取代对溶菌酶环区抗原特异性的影响。
Mol Immunol. 1980 Jan;17(1):37-46. doi: 10.1016/0161-5890(80)90122-4.
Zotero 插件