Human & Environmental Safety Department, The Procter & Gamble Company, 5299 Spring Grove Avenue, 45217, Cincinnati, OH.
J Am Soc Mass Spectrom. 1992 Jul;3(5):575-81. doi: 10.1016/1044-0305(92)85035-I.
This article describes the interfacing of a normal phase fused silica capillary high performance liquid chromatography system to a magnetic sector mass spectrometer by using continuous flow fast atom bombardment (CFFAB). While the performance of CFFAB using reversed phase techniques is well understood, there is very little if any documentation on interfacing nonaqueous normal phase systems with CFFAB. This article describes the use of packed fused silica capillary liquid chromatography columns and the corresponding normal phase solvent systems. The experimental parameters required with nonaqueous solvent systems differ significantly from those of aqueous solvent systems. Ditallowdimethylammonium chloride (DTDMAC), a cationic surfactant commonly used as the active ingredient in fabric softener products, was chosen as a model compound to demonstrate the technique. DTDMAC was identified in a commercially available fabric softener product by using on-line normal phase liquid chromatography/mass spectrometry with accurate mass and tandem mass spectrometry.
本文描述了通过连续流动快速原子轰击（CFFAB）将正相熔融石英毛细管高效液相色谱系统与扇形磁场质谱仪连接的方法。虽然已经很好地了解了使用反相技术的 CFFAB 的性能，但关于用 CFFAB 连接非水相正相系统的文档很少。本文描述了使用填充熔融石英毛细管液相色谱柱和相应的正相溶剂系统。与水溶剂系统相比，非水溶剂系统所需的实验参数有很大的不同。双十八烷基二甲基氯化铵（DTDMAC）是一种常用的阳离子表面活性剂，作为织物柔软剂产品的有效成分，被选为模型化合物来演示该技术。通过使用在线正相液相色谱/质谱联用仪进行精确质量和串联质谱分析，在市售的织物柔软剂产品中鉴定出 DTDMAC。
