一锅法合成 7,9-二烷基嘌呤-8-酮类似物：广泛的底物范围。
One-pot synthesis of 7,9-dialkylpurin-8-one analogues: broad substrate scope.
机构信息
School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University , Xinxiang 453007, Henan, China.
出版信息
J Org Chem. 2013 Dec 20;78(24):12629-36. doi: 10.1021/jo402248d. Epub 2013 Nov 19.
PMID:24236578
Abstract
The one-pot and direct synthesis of 7,9-dialkylpurin-8-one analogues with broad substrate scope has been developed. This copper-catalyzed C-H oxidation reaction could avoid multistep synthesis of quaternary ammonium salts and expand the scope of halogenated alkanes. Moreover, benzimidazole derivatives are also applicable in the catalytic system.
摘要
一锅法、直接合成具有广泛底物范围的 7,9-二烷基嘌呤-8-酮类似物的方法已经开发出来。该铜催化的 C-H 氧化反应可以避免季铵盐的多步合成，并扩大了卤代烷烃的范围。此外，苯并咪唑衍生物也适用于催化体系。
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