Khan Haseena Banu Hedayathullah, Shanmugavalli R, Rajendran Deepa, Bai Mookambikai Ramya, Sorimuthu Subramanian
Department of Advanced Biochemistry & Molecular Biology, University of Madras, Guindy Campus, Chennai, India.
J Diet Suppl. 2013 Dec;10(4):335-44. doi: 10.3109/19390211.2013.830677.
Psidium guajava is an important plant of high medicinal value and has been used in traditional systems of medicine against various ailments. The antidiabetic effect of the ethanolic extract of Psidium guajava leaves and also its protective effect on altered glucose metabolism was evaluated in streptozotocin (stz)-induced diabetic rat model. Diabetes was induced in rats by means of intraperitoneal injection of 50-mg/kg body weight (b.wt.) of stz. Diabetes-induced rats were randomly divided into two groups. One group of rats was treated with Psidium guajava leaf extract at a dosage of 300-mg/kg b.wt. and the other group of rats was treated with the standard drug glyclazide at a dosage of 5-mg/kg b.wt. for 30 days. The blood glucose levels, plasma insulin, Hb, HbA1c were measured. The effect on the drug on altered glucose metabolizing enzymes were also studied. Treatment with Psidium guajava extract showed a significant reduction in blood glucose and HbA1c levels and a significant increase in plasma insulin levels. The drug also significantly restored the activities of carbohydrate metabolizing enzymes. This suggests that the potential antidiabetic effect of the ethanolic extract of the Psidium guajava leaves may be due to the presence of flavonoids and other phenolic components present in the drug.
番石榴是一种具有重要药用价值的植物，已被用于传统医学体系中治疗各种疾病。在链脲佐菌素（STZ）诱导的糖尿病大鼠模型中，评估了番石榴叶乙醇提取物的抗糖尿病作用及其对葡萄糖代谢改变的保护作用。通过腹腔注射50毫克/千克体重的STZ诱导大鼠患糖尿病。将诱导糖尿病的大鼠随机分为两组。一组大鼠用300毫克/千克体重的番石榴叶提取物治疗，另一组大鼠用5毫克/千克体重的标准药物格列齐特治疗30天。测量血糖水平、血浆胰岛素、血红蛋白、糖化血红蛋白。还研究了药物对葡萄糖代谢酶改变的影响。用番石榴提取物治疗后，血糖和糖化血红蛋白水平显著降低，血浆胰岛素水平显著升高。该药物还显著恢复了碳水化合物代谢酶的活性。这表明番石榴叶乙醇提取物的潜在抗糖尿病作用可能归因于药物中存在的黄酮类化合物和其他酚类成分。
