Markowitz L E, Steere A C, Benach J L, Slade J D, Broome C V
JAMA. 1986 Jun 27;255(24):3394-6.
Lyme disease is an increasingly recognized tick-borne illness caused by a spirochete, Borrelia burgdorferi. Because the etiologic agent of Lyme disease is a spirochete, there has been concern about the effect of maternal Lyme disease on pregnancy outcome. We reviewed cases of Lyme disease in pregnant women who were identified before knowledge of the pregnancy outcomes. Nineteen cases were identified with onset between 1976 and 1984. Eight of the women were affected during the first trimester, seven during the second trimester, and two during the third trimester; in two, the trimester of onset was unknown. Thirteen received appropriate antibiotic therapy for Lyme disease. Of the 19 pregnancies, five had adverse outcomes, including syndactyly, cortical blindness, intrauterine fetal death, prematurity, and rash in the newborn. Adverse outcomes occurred in cases with infection during each of the trimesters. Although B burgdorferi could not be implicated directly in any of the adverse outcomes, the frequency of such outcomes warrants further surveillance and studies of pregnant women with Lyme disease.
莱姆病是一种日益被认识到的由蜱传播的疾病，由螺旋体伯氏疏螺旋体引起。由于莱姆病的病原体是螺旋体，人们一直担心孕妇患莱姆病对妊娠结局的影响。我们回顾了在知晓妊娠结局之前确诊的孕妇莱姆病病例。共确诊19例，发病时间在1976年至1984年之间。其中8名女性在孕早期感染，7名在孕中期感染，2名在孕晚期感染；另有2例感染发生时间不详。13名患者接受了针对莱姆病的适当抗生素治疗。在这19次妊娠中，有5次出现不良结局，包括并指、皮质盲、宫内胎儿死亡、早产和新生儿皮疹。在每个孕期感染的病例中均出现了不良结局。虽然不能直接将任何不良结局归咎于伯氏疏螺旋体，但这些不良结局的发生率值得对患莱姆病的孕妇进行进一步监测和研究。
