[皮肤半固体制剂中咖啡因释放度的评价]
[Evaluation of liberation of caffeine from dermal semisolids drugs].
作者信息
Kodadová Alexandra, Vitková Zuzana, Herdová Petra
出版信息
Ceska Slov Farm. 2013 Oct;62(5):220-2.
The paper deals with formulation of caffeine into dermal semisolid dosage forms - hydrogels. Caffeine was chosen as a model drug because its properties can be successfully used just in hydrogels. Protective and tranquilization effects can be used in the preparations for sunbathing, and its lipolytic and regenerative effect can be used for the treatment of androgenic alopecia or cellular bioprotection. The aim of the study was to investigate the influence of different concentrations of chitosan and caffeine on the liberation of gels. Besides, stability of the prepared samples was evaluated by means of the evaluation of their rheological parameters. Based on the obtained results, there was determined the optimal drug concentration - caffeine 0.2% (w/w) and also the gel forming substance - chitosan 2.3% (w/w).
本文探讨了将咖啡因制成皮肤半固体剂型——水凝胶。选择咖啡因作为模型药物是因为其性质仅能成功用于水凝胶中。其保护和镇静作用可用于防晒制剂，其脂肪分解和再生作用可用于治疗雄激素性脱发或细胞生物保护。本研究的目的是研究不同浓度的壳聚糖和咖啡因对凝胶释放的影响。此外，通过评估所制备样品的流变学参数来评价其稳定性。根据所得结果，确定了最佳药物浓度——0.2%（w/w）的咖啡因以及凝胶形成物质——2.3%（w/w）的壳聚糖。
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